13 registrations that name mucuna pruriens as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 13 registrations
Status
All 13 registrations
RecruitingNCT06340438
Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals
No phase
Aalborg University
About 46 people
Started Apr 27, 2024
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 46 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Histamine; Cowhage.
Healthy men and women
18-60 years
Speak and understand English
The exclusion criteria are on the listing.
What it tests, as registered
Histamine; Cowhage
Registered summary
This project aims to investigate the relationship between different dimensions of catastrophizing (rumination, magnification, and helplessness) as well as some specific personality traits related to catastrophizing tendencies like anxiety sensitivity and fear sensitivity in the modulation of itch and pain intensities in an experimental setting.
Where, as registered
No US site; Denmark (1).
RecruitingNCT06081946
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
No phase
Aalborg University
About 30 people
Started Dec 15, 2023
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Histamine; Cowhage; Sleep Fragmentation.
Healthy men and women
18-60 years
Speak and understand English
Access to a smartphone during the experimental nights
The exclusion criteria are on the listing.
What it tests, as registered
Histamine; Cowhage
Registered summary
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: * To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them. * To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples. * To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep fragmentation.
Where, as registered
No US site; Denmark (1).
RecruitingNCT06081998
Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity
No phase
Aalborg University
About 30 people
Started Nov 1, 2023
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Histamine; Cowhage; Sleep Deprivation.
Healthy men and women
18-60 years
Speak and understand English
Access to a smartphone during the experimental nights
The exclusion criteria are on the listing.
What it tests, as registered
Histamine; Cowhage
Registered summary
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch: * To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them. * To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples. * To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep. The full summary is on the listing.
Where, as registered
No US site; Denmark (1).
RecruitingNCT06503523
The Effects of Performing a Motor Imagery Task on Cortical Excitability During Acute Experimental Muscle Pain and Acute Itch
No phase
Aalborg University
About 30 people
Started Oct 1, 2024
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 30 people at 2 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Itch; Pain.
Healthy men and women
18-60 years
Speak and understand English
The exclusion criteria are on the listing.
What it tests, as registered
Hypertonic Saline; Histamine; Cowhage; Transcranial magnetic stimulation (TMS)
Registered summary
The aim of this project is to determine the effects of performing a motor imagery task on cortical excitability during acute experimental muscle pain (induced by hypertonic saline), acute histaminergic itch (induced by histamine), and non-histaminergic itch stimulation (triggered by Cowhage). We hypothesize that motor imagery will counteract the alterations in cortical excitability observed during experimental muscle pain and both itch models.
Where, as registered
No US site; Denmark (2).
RecruitingNCT07122973
Topographical Distribution of Itch and Pain Receptors
No phase
Aalborg University
About 30 people
Started Sep 17, 2025
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Pain; Itch.
The experiment consists of three experimental sessions conducted on three consecutive days. In all experimental sessions, the participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. In the first session, we will mark six test areas in your face (three on each side on jaw, cheek, and temple, respectively). The full summary is on the listing.
Where, as registered
No US site; Denmark (1).
RecruitingNCT07247695
Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch
No phase
Aalborg University
About 30 people
Started Nov 3, 2025
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: ITCH.
Healthy men and women
18-60 years
Speak and understand English
The exclusion criteria are on the listing.
What it tests, as registered
Histamine; Cowhage
Registered summary
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. Afterwards, two areas will be selected on each forearm of the subjects. The four areas will be treated with the same vehicle cream for 20 minutes, in order to test the placebo effect. At the end of the cream application, two areas will be randomly treated with histamine while cowhage will be applied on the other two areas. The full summary is on the listing.
Where, as registered
No US site; Denmark (1).
RecruitingNCT06328543
Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)
No phase
Aalborg University
About 26 people
Started Nov 1, 2024
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 26 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Histamine; Cowhage.
Healthy men and women
18-60 years
Speak and understand Englis
The exclusion criteria are on the listing.
What it tests, as registered
Histamine; Cowhage
Registered summary
In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli. The hypothesis behind this study (temporal summation) is that two overlapped applications of pruritogens will result in a higher itch sensation compared with a single application.
Where, as registered
No US site; Denmark (1).
RecruitingNCT06328530
Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation)
No phase
Aalborg University
About 24 people
Started Apr 1, 2024
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 24 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Histamine; Cowhage.
Healthy men and women
18-60 years
Speak and understand English
The exclusion criteria are on the listing.
What it tests, as registered
Cowhage; Histamine
Registered summary
In This experiment, the investigators would like to design a new itch model based on the spatial summation of pruritic stimuli. The hypothesis behind this study (spatial summation) is that two simultaneous applications of pruritogens will result in higher itch sensation compared with a single application of pruritogen.
Where, as registered
No US site; Denmark (1).
RecruitingNCT06503510
Role of Interleukin-13 Pathways on Pain and Itch Sensitivity
No phase
Aalborg University
About 20 people
Started Jan 6, 2025
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 20 people at 3 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Itch.
Atopic dermatitis (AD) is as chronic, inflammatory skin disorder affecting 20% of the world's population. Intense itch and skin pain are the main symptoms. Research has shown that the proteins interleukins are involved in inflammation and itch in atopic dermatitis. The medicinal product called Lebrikizumab, used for treatment of AD, has shown to block the interleukin called IL-13. The purpose of this experiment is to evaluate the role of IL-13 in itch in both healthy subjects and people with atopic dermatitis.
Where, as registered
No US site; Denmark (3).
Not yet recruitingNCT07203274
The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch
No phase
Aalborg University
About 30 people
Starts May 1, 2026 (estimated)
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Itchiness.
It is well known that itch and pain have many communalities in terms of pathways and molecules involved. Therefore, it is very important to investi-gate different substances that work against both pain and itching. The substances delgocitinib and lidocaine have both been shown to relieve various types of pain. We therefore assume that these creams will be also able to relieve itching. The purpose of this trial experiment is therefore to investigate the effect of delgocitinib, lidocaine and their combination on experimentally induced itching.
Where, as registered
No US site; Denmark (1).
Not yet recruitingNCT07255092
Mechanisms Underlying the Nocibo Effect of Contagious Itch. in Both Histaminergic and Nonhistaminergic Itch
No phase
Aalborg University
About 30 people
Starts Dec 1, 2025 (estimated)
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: ITCH.
18-60 years
Speak and understand English
The exclusion criteria are on the listing.
What it tests, as registered
Histamine; Cowhage (Mucuna Pruriens); Placebo
Registered summary
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. Afterwards, three areas will be selected on each forearm of the subjects. Two areas will be treated with histamine, two with cowhage, and two with vehicle. One application of each substance will be conducted including the contagious itch component. The full summary is on the listing.
Where, as registered
No US site; Denmark (1).
Not yet recruitingNCT07395882
A New Model to Induce Itch and Inflammation
No phase
Aalborg University
About 28 people
Starts Feb 15, 2026 (estimated)
In plain words A study of mucuna pruriens in people 18 to 60, run by Aalborg University. It plans to enroll about 28 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Itching.
Healthy men and women
18-60 years
Speak and understand English
The exclusion criteria are on the listing.
What it tests, as registered
Cowhage (Mucuna Pruriens); Histamine; Heat
Registered summary
This project aims to create a reliable, long-lasting itch model by synergistically combining thermal pre-conditioning with the application of histamine or cowhage.
Where, as registered
No US site; Denmark (1).
Not yet recruitingNCT07755930
Marsili Syndrome as a Gateway to Novel Analgesic Targets
No phase
Aalborg University
About 4 people
Starts Aug 1, 2026 (estimated)
In plain words A study of mucuna pruriens in people 18 to 80, run by Aalborg University. It plans to enroll about 4 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 80. Conditions: Marsili Syndrome.
Congenital insensitivity to pain (CIP) comprises a group of rare genetic disorders caused by mutations in genes essential for pain sensing in humans. Among these, Marsili syndrome is caused by a dominant point mutation in the transcription factor ZFHX2, and it is characterized by markedly reduced sensitivity to noxious heat, mechanical injury, while other functions remain intact. this project aims to establish the first integrated, system-level characterization of Marsili syndrome by combining human sensory phenotyping with neurophysiological and molecular analyses. The full summary is on the listing.