40 registrations that name oxytocin as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 40 registrations
Status
Phase
20US sites across 13 states
1
2 to 4
5 to 19
20 or more
All 40 registrations
RecruitingNCT03232918
Oxytocin and Fetal Heart Rate Changes
Phase 4
Unyime Ituk
About 730 people
Started Feb 20, 2019
In plain words A Phase 4 study of oxytocin in female participants 18 to 55, run by Unyime Ituk. It plans to enroll about 730 people at 2 US sites.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 55; healthy volunteers accepted. Conditions: Fetal Bradycardia Complicating Labor and Delivery; Fetal Bradycardia During Labor; Fetal Heart Rate or Rhythm Abnormality Affecting Fetus.
Healthy nulliparous or multiparous women at term (37 > weeks' gestation)
Singleton pregnancy
Request for neuraxial analgesia
Oxytocin used for induction of labor or augmentation of labor per institutional protocols
The exclusion criteria are on the listing.
What it tests, as registered
Half dose Oxytocin
Registered summary
The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fetal heart rate changes.
Where, as registered
2 US sites in 2 states.
RecruitingNCT05488457
Oxytocin Pharmacokinetics and Pharmacodynamics
Phase 2
Stanford University
About 100 people
Started Jan 1, 2025
In plain words A Phase 2 study of oxytocin in female participants 18 to 50, run by Stanford University. It plans to enroll about 100 people at 2 US sites.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 50. Conditions: Post Partum Hemorrhage; Cesarean Section Complications; Blood Loss.
18-50 years old
intrauterine pregnancy
term (>39 weeks gestation or 37-39 weeks gestation with fetal or maternal medical indication for delivery) pregnancy
non-emergent (scheduled or unscheduled) cesarean delivery
The exclusion criteria are on the listing.
What it tests, as registered
deuterated oxytocin (d5OT)
Registered summary
Oxytocin is the first-line drug to promote contraction of the uterus and prevent atony immediately after delivery. Nonetheless, unpredictable uterine atony refractory to oxytocin affects roughly 250,000 parturients annually in the U.S. and rates are increasing. This two-part study will measure the action of oxytocin at cesarean delivery. The first part will measure the pharmacokinetics of a single intravenous (IV) dose of deuterium-labeled oxytocin. The full summary is on the listing.
Where, as registered
2 US sites in 2 states.
RecruitingNCT05754073
Oxytocin Effects on Bone in Children With Autism Spectrum Disorder
Phase 2
Elizabeth Austen Lawson
About 96 people
Started Aug 1, 2023
In plain words A Phase 2 study of oxytocin in people 6 to 18, run by Elizabeth Austen Lawson. It plans to enroll about 96 people at 2 US sites.
Who it lists and where
Who the trial lists, as registered
Lists people 6 to 18. Conditions: Autism Spectrum Disorder; Bone Health.
Ages 6 to 18 years old at Randomization
BMI greater than or equal to the 5th percentile
Expert clinical diagnosis of ASD
Availability of parent/guardian to provide informed consent
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin on bone health in children with autism spectrum disorder, ages 6-18 years old. Subjects will be randomized to receive intranasal oxytocin or placebo (30 IU, 2 times daily) for 12 months in the double-blind phase, followed by a 6-month open label phase during which all study subjects will receive intranasal oxytocin (30 IU, 2 times daily). The full summary is on the listing.
Where, as registered
2 US sites in 2 states.
RecruitingNCT05245227
Double Simultaneous Uterotonic Agents Versus Single Agent Regimen to Prevent Early Postpartum Hemorrhage
Phase 3
Stony Brook University
About 1,358 people
Started Jan 27, 2025
In plain words A Phase 3 study of oxytocin in female participants 18 and older, run by Stony Brook University. It plans to enroll about 1,358 people at 1 US site.
To determine the effectiveness of using two medications simultaneously versus one medication, as is standard of care, in preventing early postpartum hemorrhage. There have been studies that looked at giving two medications and that there were reduced odds of postpartum hemorrhage. Specific Aim 1: Determine if double simultaneous uterotonic agent regimen (misoprostol and oxytocin) is superior to single agent (oxytocin only) in reducing postpartum hemorrhage. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT04303702
The Role of Oxytocin in the Second Stage of Labor
No phase
Washington University School of Medicine
About 400 people
Started Jul 1, 2022
In plain words A study of oxytocin in female participants of any age, run by Washington University School of Medicine. It plans to enroll about 400 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists female participants of any age; healthy volunteers accepted. Conditions: Labor Complication.
Nulliparous pregnant women >/= 37 weeks gestation
Singleton pregnancies
Admission for induction of labor or spontaneous labor
The exclusion criteria are on the listing.
What it tests, as registered
Continue Oxytocin; Discontinue Oxytocin
Registered summary
This is a randomized controlled trial investigating the utility of oxytocin administration in the second stage of labor.
Where, as registered
1 US site in 1 state.
RecruitingNCT06268431
Oxytocin Rest to Reduce Cesarean Delivery
No phase
Christiana Care Health Services
About 350 people
Started Mar 19, 2024
In plain words A study of oxytocin in female participants 18 to 55, run by Christiana Care Health Services. It plans to enroll about 350 people at 1 US site.
Prolonged latent labor, defined as cervical dilation <6cm after ≥8 hours since rupture of membranes and on continuous oxytocin
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin rest
Registered summary
Prolonged labor is usually managed with continuous oxytocin infusion. "Oxytocin rest" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. "Oxytocin rest" is performed on labor and delivery units across the United States. Yet, there is no randomized or prospective data to support the practice. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT06194851
Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD
Phase 2
VA Office of Research and Development
About 240 people
Started Oct 28, 2024
In plain words A Phase 2 study of oxytocin in people 18 and older, run by VA Office of Research and Development. It plans to enroll about 240 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Post-Traumatic Stress Disorder (PTSD).
Be a Veteran (age 18 or older) with a current DSM-5 diagnosis of PTSD (as assessed by the CAPS-5 with a minimum severity score of 25) no less than 3 months after the index trauma occurred (to allow for potential natural recovery)
Be on a stable psychoactive medication regimen for at least 4 weeks (if applicable)
Be enrolled and eligible to receive care at the VASDHS
Be an intimate partner (age 18 or older) who is willing to participate in the intervention (partners can also be Veterans but cannot meet criteria for possible PTSD per the PCL-5)
5 more inclusion criteria and the exclusion criteria are on the listing.
Leveraging veterans' intimate relationships during treatment for posttraumatic stress disorder (PTSD) has the potential to concurrently improve PTSD symptoms and relationship quality. Brief Cognitive-Behavioral Conjoint Therapy (bCBCT) is a manualized treatment designed to simultaneously improve PTSD and relationship functioning for couples in which one partner has PTSD. Although efficacious in improving PTSD, the effects of CBCT on relationship satisfaction are small, especially among Veterans. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT06483659
Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
Phase 2
Brigham and Women's Hospital
About 152 people
Started Jun 1, 2025
In plain words A Phase 2 study of oxytocin in female participants 18 to 65, run by Brigham and Women's Hospital. It plans to enroll about 152 people at 1 US site.
Scheduled to undergo minimally invasive hysterectomy
No documented allergy to oxytocin
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin; Placebo
Registered summary
This is a randomized, double-blinded, placebo-controlled trial to compare the effectiveness of IV oxytocin infusion to placebo on peri-operative opioid consumption and reducing post-operative pain following a minimally invasive hysterectomy under general anesthesia.
Where, as registered
1 US site in 1 state.
RecruitingNCT06141447
Changes in Hemorrhage With Prophylactic Oxytocin for Dilation and Evacuation
Phase 2
University of Colorado, Denver
About 150 people
Started May 2, 2024
In plain words A Phase 2 study of oxytocin in female participants 18 to 55, run by University of Colorado, Denver. It plans to enroll about 150 people at 1 US site.
clinic-based D\&E at 18 weeks gestational age and above
speaks English or Spanish
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin + normal saline; Normal saline
Registered summary
The purpose of this study is to assess the effectiveness of prophylactic oxytocin on hemorrhage rates for second trimester dilation and evacuation (D\&E) in the clinic setting.
Where, as registered
1 US site in 1 state.
RecruitingNCT07119398
Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM
Phase 4
Eastern Virginia Medical School
About 80 people
Started Jul 14, 2025
In plain words A Phase 4 study of oxytocin in female participants 18 to 50, run by Eastern Virginia Medical School. It plans to enroll about 80 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 50. Conditions: Preterm PROM (Pregnancy).
Patients 18-50 years of age;
The patient is fluent in English, physically and mentally able to understand the informed consent, and is willing to participate in this study;
PPROM;
Cervical dilation </= 2cm
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Oxytocin plus Foley Catheter; Oxytocin
Registered summary
Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1). The preponderance of evidence from term pregnancies suggests that Foley catheter coupled with oxytocin is better than oxytocin alone, with a higher rate of delivery within 24 hours when a Foley catheter followed by oxytocin is compared to oxytocin alone. However, the use of a Foley catheter has not been evaluated in prospective studies on patients with PPROM.
Where, as registered
1 US site in 1 state.
RecruitingNCT06580782
Calcium Carbonate to Augment Labor Contractions
Phase 4
Weill Medical College of Cornell University
About 60 people
Started Nov 18, 2024
In plain words A Phase 4 study of oxytocin in female participants 18 and older, run by Weill Medical College of Cornell University. It plans to enroll about 60 people at 1 US site.
Nulliparas (no prior pregnancy lasting 20 weeks or greater of gestation)
Gestational age above 36 weeks, at enrollment
Present for induction or augmentation of labor inclusive of medical indication, elective induction at greater than 39 weeks' gestation, trial of labor after cesarean
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Calcium Carbonate 500 MG; Standard Dose Synthetic Pitocin
Registered summary
The investigators think that calcium carbonate can act as an assistive medication to improve contractions during labor.
Where, as registered
1 US site in 1 state.
RecruitingNCT04551482
Oxytocin for Weight Loss in Adolescents
Phase 2
Massachusetts General Hospital
About 55 people
Started Jul 28, 2021
In plain words A Phase 2 study of oxytocin in people 10 to 18, run by Massachusetts General Hospital. It plans to enroll about 55 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 10 to 18. Conditions: Obesity, Adolescent; Oxytocin.
Males and Females, 10-18 years
Obesity (BMI ≥95th percentile for age and gender)
Willingness to maintain current diet and lifestyle for the duration of study participation
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin nasal spray; Placebo
Registered summary
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in youths with obesity, ages 10-18 years old. Subjects will be randomized to receive intranasal oxytocin or placebo (1 spray per nostril, 4 times per day) for 12 weeks. Study visits include screening to determine eligibility, 2-part main study visits at baseline, week 8, and week 12, and safety check-in visits at weeks 1, and 4; phone calls at weeks 2, 6, and 10, with a safety follow-up visit 6 weeks after the last dose of study drug. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT04218409
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
Early phase 1
University of Florida
About 45 people
Started Sep 2, 2021
In plain words An early phase 1 study of oxytocin in people 21 to 45, run by University of Florida. It plans to enroll about 45 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 21 to 45; healthy volunteers accepted. Conditions: Pain.
Individuals fluent in English will participate.
Must report recreational use of opioids.
Be within 20% of their ideal body weight.
Are not currently experiencing chronic pain (pain on most days during the past 3 months)
2 more inclusion criteria and the exclusion criteria are on the listing.
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
Where, as registered
1 US site in 1 state.
RecruitingNCT05761860
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
Early phase 1
University of Florida
About 45 people
Started Sep 12, 2023
In plain words An early phase 1 study of oxytocin in people 45 to 85, run by University of Florida. It plans to enroll about 45 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 45 to 85; healthy volunteers accepted. Conditions: Pain.
Individuals fluent in English will participate.
Must report some experience with opioids (e.g., oxycodone, defined as use at least once in the subject's lifetime).
Be within 20% of their ideal body weight.
Are not currently experiencing chronic pain (pain on most days during the past 3 months)
2 more inclusion criteria and the exclusion criteria are on the listing.
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.
Where, as registered
1 US site in 1 state.
RecruitingNCT03860233
Benefits of Oxytocin in Obstructive Sleep Apnea (OSA) Patients Using Continuous Positive Airway Pressure (CPAP) Machine
Phase 1
Vivek Jain
About 40 people
Started Mar 4, 2019
In plain words A Phase 1 study of oxytocin in people 18 and older, run by Vivek Jain. It plans to enroll about 40 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Sleep Apnea; Sleep Apnea, Obstructive.
Men or women 18 years of age or older.
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin; Placebo
Registered summary
This study will investigate if an intra-nasal nose spray of the drug oxytocin can decrease the amount of pressure needed from the automatic Continuous Positive Airway Pressure (CPAP) device while sleeping decreasing some of the harmful effects of low oxygen in people with sleep apnea. This study will last 35 nights and involves spending three nights in the sleep lab at George Washington University. There are no additional costs to participants and no compensation for being involved in the study.
Where, as registered
1 US site in 1 state.
RecruitingNCT04789148
Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency
Phase 1
Elizabeth Austen Lawson
About 40 people
Started Sep 10, 2025
In plain words A Phase 1 study of oxytocin in people 18 and older, run by Elizabeth Austen Lawson. It plans to enroll about 40 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Vasopressin Deficiency.
Age 18 and above
Arginine-vasopressin deficiency
Normal FT4 or T4
Normal serum/plasma sodium
1 more inclusion criterion and the exclusion criteria are on the listing.
This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (6 IU and 24 IU) vs. placebo in adult men and women (aged 18 years and above) with arginine-vasopressin deficiency to evaluate the effect of oxytocin on anxiety, depression, and socioemotional functioning (Part A), with an optional randomized, double-blind, placebo-controlled 2-week repeated dose substudy of intranasal oxytocin 6 IU or placebo (Part B). Following a screening visit to determine eligibility, participants will return for three main study visits in Part A. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT06364228
Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia
Phase 2
University of Nebraska
About 32 people
Starts Jun 20, 2026 (estimated)
In plain words A Phase 2 study of oxytocin in female participants 50 and older, run by University of Nebraska. It plans to enroll about 32 people at 1 US site.
Currently an unpaid family caregiver to an older adult (50 years and older) with dementia for at least five hours a week for at least six months
Normal or corrected to normal vision and hearing
Mobility to travel to University of Nebraska Medical Center (UNMC) for study procedures including brain imaging
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Placebo; Oxytocin Intranasal Spray 12 International Unit (12IU); Oxytocin Intranasal Spray 24 International Unit (24IU); Functional MRI
Registered summary
More than 15 million family caregivers provide support for individuals with Alzheimer's disease (AD) or related dementias. This number is expected to grow with the increasing population of persons with dementia (PWD). Stress in caregivers to older adults with chronic diseases is already a significant public health issue because it is associated with multiple negative physical and mental health outcomes for the caregiver (e.g., depression, cardiovascular disease) and can negatively impact the health of the PWD as well. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT04949633
Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening
Phase 3
University Hospital, Tours
About 1,494 people
Started Sep 28, 2021
In plain words A Phase 3 study of oxytocin in female participants 18 and older, run by University Hospital, Tours. It plans to enroll about 1,494 people at 14 sites, none in the US.
5 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Prostaglandins; Oxytocin
Registered summary
Twenty-two percent of deliveries in France are induced. In cases where labor is induced and cervix is unfavorable, cervical ripening prior oxytocin administration is advised in order to reduce the risk of cesarean delivery. Cervical ripening agents, pharmacological (prostaglandins) or mechanical are administered during 24 hours. After 24 hours, most women will be either delivered or in labor but 25% of women will require further induction of labor. For 16% of women who undergo cervical ripening, whatever the cervical ripening method, the cervix remains unchanged after 24 hours. The full summary is on the listing.
Where, as registered
No US site; France (14).
RecruitingNCT07366359
PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)
No phase
National Hospital of Obstetrics and Gynecology
About 450 people
Started Feb 10, 2026
In plain words A study of oxytocin in female participants 18 and older, run by National Hospital of Obstetrics and Gynecology. It plans to enroll about 450 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 and older. Conditions: Premature Rupture of Fetal Membranes; Labor, Induced; Cervical Ripening.
Maternal age ≥ 18 years
Gestational age from 37 to 42 weeks, determined by last menstrual period or by a first- or second-trimester ultrasound
Live singleton fetus
Prelabor rupture of membranes (PROM) confirmed by at least one of the following:
6 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Sequential Induction: Dinoprostone Followed by Oxytocin; Immediate Oxytocin Induction
Registered summary
This study is being done to learn more about the best way to start labor for pregnant women whose water breaks at term before labor begins, a condition called term prelabor rupture of membranes (term PROM). When this happens and the cervix is not ready for labor, it is unclear which induction method works best and is safest for mother and baby. The purpose of this study is to compare two common ways to induce labor in women with term PROM and an unfavorable cervix (Bishop score ≤ 6). The full summary is on the listing.
Where, as registered
No US site; Vietnam (1).
RecruitingNCT07636421
Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial
Phase 4
Mansoura University
About 332 people
Started Aug 8, 2026
In plain words A Phase 4 study of oxytocin in female participants 18 to 45, run by Mansoura University. It plans to enroll about 332 people at 1 site, none in the US.
Scheduled for elective non-emergency cesarean delivery
Spinal anesthesia planned and administered as the sole anesthetic technique
Singleton pregnancy at gestational age of 37 completed weeks or more
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Carbetocin; Oxytocin; Placebo Saline Infusion
Registered summary
Background: Carbetocin is an established single-dose uterotonic agent for postpartum hemorrhage prophylaxis at elective cesarean delivery. Despite its proven efficacy, many clinicians routinely add a supplemental oxytocin infusion following carbetocin administration without evidence-based justification. Concurrent oxytocin receptor stimulation may be redundant, counterproductive through receptor desensitization, or incrementally beneficial - a mechanistic uncertainty that remains unresolved in the published literature. The full summary is on the listing.
Where, as registered
No US site; Saudi Arabia (1).
RecruitingNCT07093060
The Effect of Oral Oxytocin and Atosiban on Social Attention
Early phase 1
University of Electronic Science and Technology of China
About 250 people
Started Jun 9, 2025
In plain words An early phase 1 study of oxytocin in male participants 18 to 35, run by University of Electronic Science and Technology of China. It plans to enroll about 250 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 to 35; healthy volunteers accepted. Conditions: Healhty.
Healthy male subjects without past or current psychiatric or neurological disorders
The main aim of the present study is to investigate whether orally (lingual spray) administered oxytocin influences human social attention and behaviors via oxytocin receptors and whether its effects are dose- and task-dependent.
Where, as registered
No US site; China (1).
RecruitingNCT07140237
The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban )
Early phase 1
University of Electronic Science and Technology of China
About 250 people
Starts Sep 2025 (estimated)
In plain words An early phase 1 study of oxytocin in male participants 18 to 35, run by University of Electronic Science and Technology of China. It plans to enroll about 250 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 to 35; healthy volunteers accepted. Conditions: Healthy Adult Male.
Healthy male subjects without past or current psychiatric or neurological disorders
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin lower does (24IU); Oxytocin higher does (48IU); Atosiban; Placebo
Registered summary
The main aim of the present study is to investigate whether orally (lingual spray) administered oxytocin influences human top-down attention via oxytocin receptors and whether its effects are dose- and task-dependent.
Where, as registered
No US site; China (1).
RecruitingNCT06248710
Dog Presence and Oxytocin on Trust Towards Therapists
Phase 2 and 3
Dr. Karin Hediger
About 176 people
Started Jan 29, 2024
In plain words A Phase 2 and 3 study of oxytocin in people 18 and older, run by Dr. Karin Hediger. It plans to enroll about 176 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older; healthy volunteers accepted. Conditions: Depressive Symptoms; Human-Animal Interaction.
Oxytocin has been proposed as a neuroendocrine mechanism that may mediate the relationship between dog ownership and positive health outcomes and be linked to human-dog interactions and is thought to be a mechanism of interspecies bonding. While the role of oxytocin in human bonding behaviours and social behaviour, in general, is becoming well-established the role of oxytocin in human-animal interaction and Animal-Assisted Interventions (AAI) remains unclear. The full summary is on the listing.
Where, as registered
No US site; Switzerland (1).
RecruitingNCT06333340
Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
No phase
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
About 160 people
Started Jan 14, 2025
In plain words A study of oxytocin in female participants 18 to 50, run by Samuel Lunenfeld Research Institute, Mount Sinai Hospital. It plans to enroll about 160 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 50; healthy volunteers accepted. Conditions: Post Partum Hemorrhage.
Overdistended uterus due to:
Polyhydramnios (amniotic fluid index >24 cm)
Fetal macrosomia reported on prenatal ultrasound >90th centile or > 4000 gm
Multiple gestation
5 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Oxytocin; Carbetocin
Registered summary
The goal of this study is to compare 2 medications that are commonly used to prevent excess uterine bleeding (postpartum hemorrhage, or PPH) following cesarean delivery (CD), oxytocin and carbetocin. Most of the trials evaluating the preventative role of oxytocin and carbetocin after CD have focused on patient with low-risk of PPH. The full summary is on the listing.
Where, as registered
No US site; Canada (1).
RecruitingNCT07609693
The Relationship Between Oxytocin Massage in Mothers With Insufficient Milk Production in the Early Postpartum Period and Breastfeeding Self-Efficacy and Milk Let-down Reflex: A Randomized Controlled Study
No phase
Tokat Gaziosmanpasa University
About 128 people
Started May 12, 2026
In plain words A study of oxytocin in female participants 18 and older, run by Tokat Gaziosmanpasa University. It plans to enroll about 128 people at 1 site, none in the US.
Being in the early postpartum period (within the first 24-48 hours after birth)
Having had a single, live birth via vaginal delivery or cesarean section
Having a term (≥37 weeks) and healthy baby
5 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Oxytocin Massage
Registered summary
This randomized controlled trial aims to evaluate the effects of oxytocin massage on breastfeeding self-efficacy and the milk ejection reflex among mothers experiencing insufficient milk supply in the early postpartum period. Insufficient milk supply is a common issue often linked to maternal stress, which can inhibit oxytocin release and negatively impact the milk ejection reflex and the mother's confidence in breastfeeding. By applying oxytocin massage to the thoracic paravertebral region, this study seeks to stimulate oxytocin release non-pharmacologically. The full summary is on the listing.
Where, as registered
No US site; Turkey (Türkiye) (1).
RecruitingNCT07077655
Marmet and Oxytocin Massage for Breast Milk Increase
No phase
Ege University
About 123 people
Started Aug 25, 2025
In plain words A study of oxytocin in female participants 18 to 35, run by Ege University. It plans to enroll about 123 people at 1 site, none in the US.
11 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Marmet Technique; Oxytocin Massage; Plasebo
Registered summary
This study is designed as a randomized controlled single-blind experimental study to examine the effectiveness of the oxytocin massage and Marmet technique applied to mothers who have undergone cesarean section on breast milk quantity and maternal state anxiety levels. The hypotheses of the study are as follows: H0.1. There is no difference in the amount of breast milk among mothers in the Marmet technique, oxytocin massage, and control (placebo) groups. H1.1. The full summary is on the listing.
Where, as registered
No US site; Turkey (Türkiye) (1).
RecruitingNCT06181396
Time of Oxytocin Initiation at 2nd Stage of Labor and Adverse Outcomes
No phase
Rambam Health Care Campus
About 120 people
Started Oct 1, 2023
In plain words A study of oxytocin in female participants 18 and older, run by Rambam Health Care Campus. It plans to enroll about 120 people at 1 site, none in the US.
Oxytocin administration initiated or renewed during second stage of labor
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin
Registered summary
Early oxytocin administration at the 2nd stage of labor is associated with a higher rate of vaginal delivery, shorter second stage duration, and fewer adverse maternal and neonatal outcomes.
Where, as registered
No US site; Israel (1).
RecruitingNCT07265180
Oxytocin-Augmented Group Psychotherapy for Patients With Schizophrenia - an Oxytocin-dose Comparison
No phase
Charite University, Berlin, Germany
About 120 people
Started Sep 8, 2025
In plain words A study of oxytocin in people 18 to 75, run by Charite University, Berlin, Germany. It plans to enroll about 120 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 75. Conditions: Schizophrenia Spectrum Disorders (SSD).
Declaration of consent
Psychiatric diagnosis of schizophrenia (ICD-10: F2x.x spectrum) for group of patients
Mild to moderate positive symptoms (5 ≤ Positive symptoms on individual items using P-PANSS)
German should either be the native language or spoken at a native level
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Oxytocin; Placebo
Registered summary
The effectiveness of current treatment options for sociocognitive deficits and negative symptoms (NS) in schizophrenia spectrum disorders (SSD) remains limited. The cause of NS is thought to be an interference between the mesocorticolimbic dopamine system for social reward expectancy and the network for socioemotional processes. Oxytocin (OXT) may enhance functional connectivity between these neuronal networks. Lower plasma OXT levels correlate negatively with NS severity and deficits in social cognition in SSD. The full summary is on the listing.
Where, as registered
No US site; Germany (1).
RecruitingNCT07367672
The Power of Belief: Expectation-driven and Placebo Modulation of Empathic Pain
No phase
University of Electronic Science and Technology of China
About 120 people
Started Dec 1, 2025
In plain words A study of oxytocin in people 18 to 30, run by University of Electronic Science and Technology of China. It plans to enroll about 120 people at 2 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 30; healthy volunteers accepted. Conditions: Healthy Participants.
(1) Healthy subjects without any past or present psychiatric or neurological disorders; (2) Healthy subjects without any current psychotherapeutic medication.
This study investigates how belief and expectation influence empathic pain-the pain we feel when observing others in distress. Healthy adult participants will be randomly assigned to one of three groups: no-treatment control, placebo nasal spray, oxytocin-containing nasal spray. Participants in both the placebo and oxytocin conditions will be informed that they are receiving oxytocin, described as a potent agent for pain relief. During functional MRI scanning, all participants will view naturalistic pain-related videos and provide ratings of perceived subjective pain. The full summary is on the listing.
Where, as registered
No US site; China (2).
RecruitingNCT07401524
Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
Phase 4
Sheba Medical Center
About 120 people
Started May 5, 2026
In plain words A Phase 4 study of oxytocin in female participants 18 and older, run by Sheba Medical Center. It plans to enroll about 120 people at 1 site, none in the US.
The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies. Heavy bleeding after delivery, also called postpartum hemorrhage, is more common after twin births and can lead to anemia, blood transfusions, and other serious health problems. In this study, bleeding will be evaluated by measuring how much blood hemoglobin levels drop from before delivery to the day after delivery. The full summary is on the listing.
Where, as registered
No US site; Israel (1).
RecruitingNCT07425938
Oxytocin's Effects on Emotional Processing and Its Acting Routes
No phase
University of Electronic Science and Technology of China
About 120 people
Started Jan 24, 2026
In plain words A study of oxytocin in male participants 18 to 30, run by University of Electronic Science and Technology of China. It plans to enroll about 120 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 to 30; healthy volunteers accepted. Conditions: Healthy Adult Male.
Healthy subjects without past or current psychiatric or neurological disorders
The exclusion criteria are on the listing.
What it tests, as registered
placebo (compared to vasoconstrictor); vasoconstrictor (Otrivin); placebo (compared to oxytocin); oxytocin
Registered summary
The main goal of this study is to investigate the modulatory effects of intranasally administrated oxytocin on the processing of emotional stimuli and its acting routes.
Where, as registered
No US site; China (1).
RecruitingNCT07838493
Oromucosal Oxytocin and Vasopressin Modulation of Emotional Face Attention
No phase
University of Electronic Science and Technology of China
About 120 people
Starts Sep 18, 2026 (estimated)
In plain words A study of oxytocin in people 18 to 30, run by University of Electronic Science and Technology of China. It plans to enroll about 120 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 30; healthy volunteers accepted. Conditions: Healhty.
Healthy subjects without past or current psychiatric or neurological disorders
Normal or corrected-to-normal vision
Eligible for MRI scanning and willing to undergo blood sampling and study treatment administration
For naturally cycling female participants, willingness and ability to complete the experimental session within the predefined menstrual-cycle phase, determined using menstrual history and urinary luteinizing hormone (LH) testing
1 more inclusion criterion and the exclusion criteria are on the listing.
The goal of this clinical trial is to learn how 24 IU oxytocin (OT) and 24 IU arginine vasopressin (AVP), administered through the oral mucosa, affect attention to emotional faces and related brain activity in healthy adults. The study will compare OT and AVP with a placebo (PLC). The main questions it aims to answer are: 1. The full summary is on the listing.
Where, as registered
No US site; China (1).
RecruitingNCT06222749
Oxytocin and Reward Processing in Women
No phase
International Research Training Group 2804
About 100 people
Started Feb 16, 2024
In plain words A study of oxytocin in female participants 18 to 40, run by International Research Training Group 2804. It plans to enroll about 100 people at 1 site, none in the US.
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth. The neuropeptide furthermore affects reward processing and metabolic functions such as eating behavior and body weight. Oxytocin receptors are present in brain regions associated with the processing of rewards, e.g., ventral tegmental area (VTA), nucleus accumbens (NAcc) and nucleus stria terminalis. Previous studies indicate that oxytocin interacts with sex hormones such as estradiol in a sex-specific manner. The full summary is on the listing.
Where, as registered
No US site; Germany (1).
RecruitingNCT06285396
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
No phase
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
About 96 people
Started Mar 18, 2024
In plain words A study of oxytocin in female participants 19 to 45, run by Samuel Lunenfeld Research Institute, Mount Sinai Hospital. It plans to enroll about 96 people at 1 site, none in the US.
Patients who have given consent to participate in the study
Patients with gestational age 37-41 weeks
Patients previously diagnosed with either Type II or Gestational diabetes. For the healthy control group, no previous diagnosis is required for inclusion
Patients of 19-45 years
5 more inclusion criteria and the exclusion criteria are on the listing.
The goal of this study is to learn about how medication that is used to help treat low blood pressure during a Cesarean delivery (CD) can cause changes to the uterine muscle tissue and its ability to contract, in patients with Type II and gestational diabetes. Spinal anesthesia administered during elective CD has been known to cause hypotension (low blood pressure) as a side effect during the procedure, and is prevented by administration of vasopressors (medication to raise blood pressure) by the anesthesiologist after the delivery of the baby. The full summary is on the listing.
Where, as registered
No US site; Canada (1).
RecruitingNCT07162584
Oxytocin and Human Defensive Responses in a Dynamic Situation
No phase
University of Electronic Science and Technology of China
About 80 people
Started Sep 13, 2025
In plain words A study of oxytocin in people 18 to 35, run by University of Electronic Science and Technology of China. It plans to enroll about 80 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 35; healthy volunteers accepted. Conditions: Healthy.
Healthy subjects without past or current psychiatric or neurological disorders
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin nasal spray; Placebo
Registered summary
The presnet study is to investigate the effect of intranasal oxytocin (24 IU) treatment on modulating how human responsd to threat in a dynamic situation.
Where, as registered
No US site; China (1).
RecruitingNCT07551882
Oxytocin Plus Self-compassion Training in Borderline Personality Disorder
Phase 2
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
About 80 people
Started Jan 10, 2024
In plain words A Phase 2 study of oxytocin in people 18 to 50, run by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau. It plans to enroll about 80 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 50. Conditions: Self-compassion Training (SCT) Plus Intranasal Oxytocin; Self-compassion Training (SCT) Plus Intranasal Placebo.
Diagnosis of Borderline Personality Disorder (BPD) according to two semi-structured interviews: the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) and the Revised Diagnostic Interview for Borderlines…
Aged between 18 and 50 years, inclusive.
Pharmacological treatment stability maintained throughout the intervention period.
Previous treatment for BPD, specifically Standard Dialectical Behavior Therapy (DBT) or DBT Skills Training.
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Intranasal Oxytocin (IN-OXT); Intranasal Placebo; Self-Compassion Training (SCT)
Registered summary
Background: Borderline personality disorder (BPD) is a frequentand serious psychiatric disorder characterized by a persistent pattern of instability in relationships, affect and self-image. Although long-term follow-up prospective studies have shown high clinical remission rates, they also point out that usually persist social functioning deficits, comorbidity, isolation, chronic affective clinic and life dissatisfaction. Self-compassion training (SCT) could be an effective strategy targeting self-criticism, shame and chronic feelings of worthlessness, as well as increasing resilience. The full summary is on the listing.
Where, as registered
No US site; Spain (1).
RecruitingNCT07559656
Oxytocin's Effects on Real Time-fMRI Neurofeedback Training of Anterior Insula Activity
No phase
University of Electronic Science and Technology of China
About 80 people
Starts Apr 26, 2026 (estimated)
In plain words A study of oxytocin in male participants 18 to 30, run by University of Electronic Science and Technology of China. It plans to enroll about 80 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 to 30; healthy volunteers accepted. Conditions: Healthy.
Healthy subjects without any past or present psychiatric or neurological disorders.
The exclusion criteria are on the listing.
What it tests, as registered
Intranasal oxytocin; Intranasal placebo
Registered summary
The primary aim of this study is to investigate whether intranasal oxytocin can modulate the real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback training effects by facilitating the use of an interoceptive strategy.
Where, as registered
No US site; China (1).
RecruitingNCT07815496
The Effects of Oxytocin on Fairness Perception and Related Prosocial Behaviors
No phase
University of Electronic Science and Technology of China
About 80 people
Started Sep 5, 2026
In plain words A study of oxytocin in people 18 to 35, run by University of Electronic Science and Technology of China. It plans to enroll about 80 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 35; healthy volunteers accepted. Conditions: Healthy Adult Participants.
Healthy subjects without past or current psychiatric or neurological disorders.
The exclusion criteria are on the listing.
What it tests, as registered
Oxytocin nasal spray; Placebo
Registered summary
This study aims to investigate the modulation of intranasally administered oxytocin (24 IU) on human fairness perception and related prosocial behaviors.
Where, as registered
No US site; China (1).
RecruitingNCT07409753
Effects Of Intravenous Oxytocin On Peripheral Sensory Afferents Using Microneurography
Phase 2
Wake Forest University Health Sciences
About 60 people
Started Oct 22, 2025
In plain words A Phase 2 study of oxytocin in people 18 to 65, run by Wake Forest University Health Sciences. It plans to enroll about 60 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65; healthy volunteers accepted. Conditions: Acute Pain.
In good health as determined by the Principal Investigator (PI) or co-investigators based on prior medical history, current psychiatric assessment, and clinical assessment of lab tests.
Female participants of child-bearing potential including those < 1 year post-menopausal, must be practicing highly effective methods of birth control such as hormonal methods (e.g., combined oral, implantable, injectable, or transdermal…
Normal blood pressure (systolic 90-140 mmHg; diastolic 50-90 mmHg) resting heart rate 45-100 beats per minute) without medication.
Proficient in Swedish or English
The exclusion criteria are on the listing.
What it tests, as registered
Intravenous Oxytocin; Intravenous Placebo
Registered summary
The goal of this clinical trial is to learn if oxytocin reduces pain in a small area of skin after pulses of non-burning heat by changing how nerves in the heated area react to pressing a thin, bendable plastic bristle and a thick, non-bending plastic bristle in adult, healthy participants. The man questions it aims to answer are: Does oxytocin increase the number of times a fiber which normally responds only to the thin bristle fires (sends a signal) after the heat pulses. The full summary is on the listing.
Where, as registered
No US site; Sweden (1).
RecruitingNCT06676774
Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls
Phase 2
University Hospital, Basel, Switzerland
About 42 people
Started May 16, 2025
In plain words A Phase 2 study of oxytocin in people 18 and older, run by University Hospital, Basel, Switzerland. It plans to enroll about 42 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older; healthy volunteers accepted. Conditions: Arginine Vasopressin Deficiency; Diabetes Insipidus.
Adult healthy volunteers
Matched for age, sex, BMI, and oestrogen replacement/menopause/hormonal contraceptives to patients.
No medication, except hormonal contraception
Adult patients with a confirmed diagnosis of AVP deficiency based on accepted criteria6
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Oxytocin nasal spray; Placebo
Registered summary
This study aims to investigate the potential beneficial effects of intranasal oxytocin compared to placebo on emotion recognition and acute psychosocial stress in patients with arginine vasopressin deficiency compared to matched healthy controls.