Vitamin B6 (pyridoxine vs P5P) and energy

What 2 graded rows on vitamin b6 (pyridoxine vs p5p) agree on for energy, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Vitamin B6 (pyridoxine vs P5P) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Vitamin B6 (pyridoxine vs P5P) page, with its PubMed record.

Supplement

Vitamin B6 (pyridoxine vs P5P) Choose another

2 rows · 401 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade B, is a randomized trial of 342 people (1995) and found an improvement.

The rows run from 59 to 342 people, published from 1991 to 1995: 2 single studies.

1 improved · 1 mixed

Grade BNausea in early pregnancy · Improved
RCT · n 342 · 1995 · Pregnant women at 17 weeks' gestation or earlier, Thailand
30 mg/day · 5 days
Nausea scores fell significantly more with pyridoxine than placebo (p = 0.0008). The drop in vomiting episodes did not reach significance (p = 0.0552).
Row on the Vitamin B6 (pyridoxine vs P5P) page · PubMed 7573262 (opens PubMed)
Grade DNausea in early pregnancy, by severity · Mixed
RCT · n 59 · 1991 · Pregnant women with nausea and vomiting
25 mg every 8 hours (75 mg/day) · 72 hours
In women with severe nausea, nausea scores improved more with B6 (4.3 vs 1.8 points). In mild-to-moderate nausea and in the group as a whole there was no significant difference.
Row on the Vitamin B6 (pyridoxine vs P5P) page · PubMed 2047064 (opens PubMed)