TUDCA (tauroursodeoxycholic acid) and gut
What 3 graded rows on tudca (tauroursodeoxycholic acid) agree on for gut, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the TUDCA (tauroursodeoxycholic acid) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the TUDCA (tauroursodeoxycholic acid) page, with its PubMed record.
Your question
TUDCA (tauroursodeoxycholic acid) and gut
3 rows · 241 peopleThey agree: all 3 rows found an improvement.
- CGrade C× 1
- DGrade D× 2
- Rows
- 3
- Trials
- 3
- People
- 241
What the rows share
From the rowsThe best-graded row, grade C, is a randomized trial of 199 people (2016) and found an improvement.
The rows run from 18 to 199 people, published from 1996 to 2016: 3 single studies.
The rows
3 improved- CGrade CLiver enzyme (ALP) response compared with the drug UDCA · Improved
RCT · n 199 · 2016 · Adults in China with primary biliary cholangitis
750 mg/day (250 mg three times a day) · 24 weeks
ALP fell by more than 25% in 76% of the TUDCA group and 81% of the UDCA group, a difference that was not significant; itching rose only in the UDCA group. There was no placebo group.
Row on the TUDCA (tauroursodeoxycholic acid) page · PubMed 27893675 (opens PubMed)
- DGrade DLiver enzymes at three TUDCA doses · Improved
RCT · n 24 · 1996 · Adults with primary biliary cirrhosis
500, 1,000 or 1,500 mg/day · 6 months
Liver enzymes fell within the first month at all three doses with no clear difference between doses; diarrhea was the only side effect.
Row on the TUDCA (tauroursodeoxycholic acid) page · PubMed 8674405 (opens PubMed)
- DGrade DLiver enzymes compared with UDCA · Improved
RCT · n 18 · 2013 · Adults in China with liver cirrhosis
750 mg/day · 6 months
ALT, AST and ALP fell from baseline with TUDCA (AST only with UDCA); fibrosis markers did not change in either group. Both were well tolerated.
Row on the TUDCA (tauroursodeoxycholic acid) page · PubMed 23592128 (opens PubMed)