TMG (trimethylglycine, betaine) and metabolic

What 2 graded rows on tmg (trimethylglycine, betaine) agree on for metabolic, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the TMG (trimethylglycine, betaine) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the TMG (trimethylglycine, betaine) page, with its PubMed record.

Supplement

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2 rows · 258 people

Split. 1 row found an improvement and 1 found no difference.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

Trial sizeStudy designWhen publishedGrade

The best-graded row, grade C, is a meta-analysis of 195 people (2019) and found an improvement.

The row that found an improvement was larger: 195 people, against 63 people for the row that found no difference.

The row that found an improvement is a pooled review of several trials; the row that found no difference is a single study.

The row that found an improvement is newer (2019) than the row that found no difference (2011).

The best grade is C among the row that found an improvement, and D among the row that found no difference.

1 improved · 1 no difference

Grade CBody fat mass · Improved
Meta-analysis · n 195 · 2019 · Adults in 6 randomized trials
Varied across trials · Varied across trials
Total body fat fell by 2.53 kg and body fat percentage by 2.44 points; body weight and BMI did not change.
Row on the TMG (trimethylglycine, betaine) page · PubMed 31623137 (opens PubMed)
Grade DMetabolic syndrome risk factors in healthy adults · No difference
RCT · n 63 · 2011 · Healthy young adults
4 g/day · 6 months
Little effect on metabolic risk factors; homocysteine lowering was weak, and plasminogen activator inhibitor 1 rose with betaine.
Row on the TMG (trimethylglycine, betaine) page · PubMed 20978525 (opens PubMed)