Strontium and fractures
What 3 graded rows on strontium agree on for fractures, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Strontium page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Strontium page, with its PubMed record.
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Strontium and fractures
3 rows · 11,822 peopleThey agree: all 3 rows found an improvement.
- AGrade A× 1
- BGrade B× 2
- Rows
- 3
- Trials
- 4
- People
- 11,822
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade A, is a meta-analysis of 5,082 people (2006) and found an improvement.
The rows run from 1,649 to 5,091 people, published from 2004 to 2006: 1 pooled review and 2 single studies.
The rows
3 improved- AGrade AVertebral and non-vertebral fractures (strontium ranelate, pooled) · Improved
Meta-analysis, 2 studies · n 5,082 · 2006 · Postmenopausal women with osteoporosis (4 trials; vertebral analysis from 2 trials)
2 g/day (lower doses 0.125–1 g/day in other arms) · 3 years
Vertebral fractures fell by 37% (RR 0.63) and non-vertebral fractures by 14% (RR 0.86; n = 6,572). Diarrhoea was more common, and vascular and nervous-system side effects were slightly increased with 2 g/day.
- BGrade BNon-vertebral and hip fractures (strontium ranelate) · Improved
RCT · n 5,091 · 2005 · Postmenopausal women with osteoporosis (TROPOS trial)
2 g/day · 3 years (main analysis of a 5-year study)
All non-vertebral fractures fell by 16% (P = 0.04) and major fragility fractures by 19%; in a high-risk subgroup (age 74+ with very low hip BMD) hip fractures fell by 36% (P = 0.046).
- BGrade BNew vertebral fractures (strontium ranelate) · Improved
RCT · n 1,649 · 2004 · Postmenopausal women with osteoporosis and at least one vertebral fracture (SOTI trial)
2 g/day · 3 years
New vertebral fractures fell by 49% in year 1 and 41% over 3 years (RR 0.59); lumbar spine BMD rose 14.4% and femoral neck 8.3%. Serious adverse events did not differ in the published report.