Streptococcus salivarius K12 and ear infections

What 2 graded rows on streptococcus salivarius k12 agree on for ear infections, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Streptococcus salivarius K12 page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Streptococcus salivarius K12 page, with its PubMed record.

Supplement

Streptococcus salivarius K12 Choose another

2 rows · 1,195 people

They agree: both rows found no difference.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

Every row is graded No effect, our grade for adequately powered trials that found no effect.

The rows run from 368 to 827 people, published from 2023 to 2026: 2 single studies.

2 no difference

No effectEar infections needing antibiotics in day-care children · No difference
RCT · n 827 · 2023 · Children aged 1 to 6 attending 50 day care centres (Oulu, Finland)
1 billion CFU once daily in the evening · 6 months
34 children (8.2%) on K12 and 24 (5.8%) on placebo had at least one ear infection treated with antibiotics (relative risk 1.42, 95% CI 0.86 to 2.34; P = .17). Time to first episode did not differ.
Row on the Streptococcus salivarius K12 page · PubMed 37917062 (opens PubMed)
No effectEar infections and respiratory infections in infants · No difference
RCT · n 368 · 2026 · Infants from the general population (New Zealand), dosed from 6 to 24 months of age
Daily (amount not stated in the abstract) · 18 months (age 6 to 24 months)
Doctor-recorded ear infections occurred in 37% on K12 and 39% on placebo (rate ratio 0.84, 95% CI 0.57 to 1.24); time to first episode, respiratory infections, antibiotic prescribing and healthcare use did not differ.
Row on the Streptococcus salivarius K12 page · PubMed 42693329 (opens PubMed)