Spermidine and memory
What 2 graded rows on spermidine agree on for memory, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Spermidine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Spermidine page, with its PubMed record.
Your question
Spermidine and memory
2 rows · 130 peopleSplit. 1 row found an improvement and 1 found no difference.
- CGrade C× 1
- DGrade D× 1
- Rows
- 2
- Trials
- 2
- People
- 130
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 100 people (2022) and found no difference.
The row that found no difference was larger: 100 people, against 30 people for the row that found an improvement.
The row that found no difference ran longer (12 months) than the row that found an improvement (3 months).
The row that found no difference is newer (2022) than the row that found an improvement (2018).
The best grade is C among the row that found no difference, and D among the row that found an improvement.
The rows
1 improved · 1 no difference- DGrade DMemory performance in a pilot trial · Improved
Pilot RCT · n 30 · 2018 · Cognitively intact adults aged 60–80 with subjective cognitive decline, described as at risk for Alzheimer's disease
Not stated in the abstract · 3 months
Memory performance was moderately better than placebo (Cohen's d 0.77, confidence interval touching zero), and mnemonic discrimination improved in the spermidine group.
- CGrade CMemory performance (mnemonic discrimination) · No difference
RCT · n 100 · 2022 · Adults aged 60–90 with subjective cognitive decline (SmartAge trial)
0.9 mg spermidine/day · 12 months
No significant change in memory performance or secondary outcomes versus placebo. Adverse events were balanced between groups.