Serum Bovine Immunoglobulin (SBI) and diarrhea

What 2 graded rows on serum bovine immunoglobulin (sbi) agree on for diarrhea, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Serum Bovine Immunoglobulin (SBI) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Serum Bovine Immunoglobulin (SBI) page, with its PubMed record.

Supplement

Serum Bovine Immunoglobulin (SBI) Choose another

2 rows · 111 people

Split. 1 row found an improvement and 1 found no difference.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

Trial sizeHow longWhen publishedGrade

The best-graded row, grade C, is a randomized trial of 103 people (2017) and found no difference.

The row that found no difference was larger: 103 people, against 8 people for the row that found an improvement.

The row that found no difference ran longer (5 months) than the row that found an improvement (8 weeks).

The row that found no difference is newer (2017) than the row that found an improvement (2013).

The best grade is C among the row that found no difference, and D among the row that found an improvement.

1 improved · 1 no difference

Grade DBowel movements and gut absorption in HIV enteropathy · Improved
Open-label trial · n 8 · 2013 · Adults with HIV enteropathy (USA)
2.5 g twice daily · 8 weeks
All eight participants reported much better symptoms with fewer bowel movements a day; gut absorption tests and duodenal immune cells were also reported to improve.
Row on the Serum Bovine Immunoglobulin (SBI) page · PubMed 23660579 (opens PubMed)
Grade CDaily unformed stools and GI symptoms · No difference
RCT · n 103 · 2017 · Adults with HIV on suppressive treatment and chronic unexplained diarrhea (USA)
2.5 or 5 g twice daily vs placebo · 4-week blinded phase, then 20 weeks open
Unformed stools fell from about 4 to under 2 a day by week 4 in every group, including placebo, and GI symptoms did not differ between SBI and placebo. Health-status scores improved in both SBI groups. Two people withdrew for adverse events possibly linked to SBI.
Row on the Serum Bovine Immunoglobulin (SBI) page · PubMed 29210625 (opens PubMed)