Serrapeptase and Post-surgical swelling
What 4 graded rows on serrapeptase agree on for Post-surgical swelling, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Serrapeptase page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Serrapeptase page, with its PubMed record.
Your question
Serrapeptase and Post-surgical swelling
4 rows · 481 peopleMostly an improvement: 3 of 4 rows, and most of the people. 1 found no difference.
- CGrade C× 3
- DGrade D× 1
- Rows
- 4
- Trials
- 4
- People
- 481
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 150 people (2009) and found no difference.
By our six checks (size, design, length, who was studied, year and grade), the two sides do not differ cleanly. The dose and how each outcome was measured are in the rows below.
The rows
3 improved · 1 no difference- CGrade CSwelling, jaw opening and pain after wisdom-tooth surgery · Improved
RCT · n 133 · 2021 · Adults having impacted lower third molars removed (Jordan; mean age 23)
10 mg three times daily, with paracetamol 1,000 mg three times daily · 5 days after surgery
On day 4, jaw opening was better and cheek swelling smaller than with placebo plus paracetamol (both P < 0.001); reported pain did not differ.
Row on the Serrapeptase page · PubMed 33653320 (opens PubMed)
- CGrade CSwelling, pain and jaw opening after wisdom-tooth surgery · Improved
Crossover RCT · n 24 · 2008 · Healthy adults with both lower third molars impacted, each side removed at a separate session (Jordan)
5 mg (frequency not stated in the abstract), with paracetamol 1,000 mg · Measured to day 7 after each operation
Cheek swelling and pain were lower than with placebo on days 2, 3 and 7 (P < 0.05); jaw opening did not differ.
Row on the Serrapeptase page · PubMed 18272344 (opens PubMed)
- DGrade DCheek swelling after sinus surgery · Improved
RCT · n 174 · 1984 · Patients having Caldwell-Luc sinus surgery, multicentre
10 mg three times daily · Day before surgery to 5 days after
Swelling was significantly less than with placebo; no side effects were reported.
Row on the Serrapeptase page · PubMed 6366808 (opens PubMed)
- CGrade CPain and swelling after wisdom-tooth surgery · No difference
RCT · n 150 · 2009 · Patients having impacted lower third molars removed (India), split across five groups
Not stated in the abstract · Postoperative period (not stated in the abstract)
Serratiopeptidase showed no significant pain-relieving or anti-swelling effect versus placebo, while ibuprofen and betamethasone reduced swelling.
Row on the Serrapeptase page · PubMed 19168326 (opens PubMed)