Sage (Salvia officinalis) and menopause
What 2 graded rows on sage (salvia officinalis) agree on for menopause, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Sage (Salvia officinalis) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Sage (Salvia officinalis) page, with its PubMed record.
Your question
Sage (Salvia officinalis) and menopause
2 rows · 358 peopleSplit. 1 row found an improvement and 1 had mixed results.
- CGrade C× 1
- DGrade D× 1
- Rows
- 2
- Trials
- 2
- At least: a review without a trial count
- People
- 358
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade C, is a meta-analysis of 310 people (2023) and reported mixed results.
The rows run from 48 to 310 people, published from 2021 to 2023: 1 pooled review and 1 single study.
The rows
1 improved · 1 mixed- DGrade DMenopausal symptoms and hot-flush severity · Improved
RCT · n 48 · 2021 · Women aged 48–56 in early postmenopause (per-protocol group of an 80-woman trial)
Tablets of 280 mg thujone-free extract (equivalent to 3,400 mg tincture) taken daily; the number of tablets a day is not stated · 4 weeks
Menopause Rating Scale scores fell 39% (15.3 to 9.3; p = 0.002 vs placebo) and hot-flush severity fell 55%, significant from week 3; sleep quality and fatigue also improved versus placebo. Three adverse events in total, none treatment-related.
Row on the Sage (Salvia officinalis) page · PubMed 33615001 (opens PubMed)
- CGrade CFrequency and severity of menopausal hot flushes · Mixed
Meta-analysis · n 310 · 2023 · Postmenopausal women in 4 trials
Varied · Varied
All 4 trials reported fewer and milder hot flushes, but the pooled effect on frequency had a confidence interval crossing zero (ES −1.12, 95% CI −2.37 to 0.14) and severity was not significant; the authors nonetheless called the frequency effect significant.
Row on the Sage (Salvia officinalis) page · PubMed 37489230 (opens PubMed)