Riboflavin (Vitamin B2) and migraine

What 4 graded rows on riboflavin (vitamin b2) agree on for migraine, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Riboflavin (Vitamin B2) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Riboflavin (Vitamin B2) page, with its PubMed record.

Supplement

Riboflavin (Vitamin B2) Choose another

4 rows · 235 people

Split. 1 row found an improvement, 1 found no difference and 2 had mixed results.

No difference or mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

Who was studiedWhen publishedGrade

The best-graded row, grade C, is a randomized trial of 55 people (1998) and found an improvement.

Only the row that found no difference names children or teens in its population.

The row that found no difference is newer (2008) than the row that found an improvement (1998).

The best grade is C among the row that found an improvement, and D among the row that found no difference.

2 rows with mixed results are left out of this comparison.

1 improved · 1 no difference · 2 mixed

Grade CMigraine attack frequency and headache days · Improved
RCT · n 55 · 1998 · Adults with migraine
400 mg/day · 3 months
Attack frequency and headache days fell more than with placebo; 59% versus 15% had at least 50% fewer headache days (number needed to treat 2.3).
Row on the Riboflavin (Vitamin B2) page · PubMed 9484373 (opens PubMed)
Grade DMigraine attacks in children · No difference
RCT · n 48 · 2008 · Children with migraine
200 mg/day · Not stated in the abstract
At least 50% fewer attacks in 12 of 27 children on riboflavin and 14 of 21 on placebo (not significant); no differences on any outcome.
Row on the Riboflavin (Vitamin B2) page · PubMed 18984840 (opens PubMed)
Grade DMigraine frequency, duration and intensity in children · Mixed
RCT · n 90 · 2018 · Children with migraine (Iran)
Low or high dose (amounts not stated in the abstract) · 12 weeks
The high dose reduced attack frequency and duration versus placebo; the low dose did not, and neither dose changed pain intensity.
Row on the Riboflavin (Vitamin B2) page · PubMed 29629048 (opens PubMed)
Grade DMigraine and tension-type headache frequency in children · Mixed
Crossover RCT · n 42 · 2010 · Children aged 6–13 with migraine
50 mg/day · Not stated in the abstract
No effect on migraine attack frequency versus placebo; tension-type headache frequency fell more with riboflavin.
Row on the Riboflavin (Vitamin B2) page · PubMed 20974610 (opens PubMed)