Pycnogenol (French maritime pine bark extract) and heart
What 3 graded rows on pycnogenol (french maritime pine bark extract) agree on for heart, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Pycnogenol (French maritime pine bark extract) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Pycnogenol (French maritime pine bark extract) page, with its PubMed record.
Your question
Pycnogenol (French maritime pine bark extract) and heart
3 rows · 3,049 peopleMostly an improvement: 2 of 3 rows, and most of the people. 1 found no difference.
- CGrade C× 3
- Rows
- 3
- Trials
- 3
- At least: a review without a trial count
- People
- 3,049
- Pooled reviews may count some twice
Where they differ
From the rowsThe best-graded row, grade C, is a meta-analysis of 1,685 people (2025) and found an improvement.
The 2 rows that found an improvement were larger: a median of 1,304 people, against 442 people for the row that found no difference.
The 2 rows that found an improvement are newer (2020 to 2025) than the row that found no difference (2014).
The rows
2 improved · 1 no difference- CGrade CBlood pressure and cardiometabolic markers · Improved
Meta-analysis · n 1,685 · 2025 · Adults in 27 randomized trials
Varied across trials · Varied
Systolic −2.26 mmHg, diastolic −2.62 mmHg, fasting glucose −6.3 mg/dL, HbA1c −0.32%, weight −1.4 kg and LDL −5.1 mg/dL versus control; no effect on HDL, triglycerides or total cholesterol.
Row on the Pycnogenol (French maritime pine bark extract) page · PubMed 39987124 (opens PubMed)
- CGrade CBlood pressure · Improved
Meta-analysis · n 922 · 2020 · Adults in 12 clinical trials
Varied across trials · Varied
Systolic −3.2 mmHg and diastolic −1.9 mmHg; the systolic effect was larger when pycnogenol was given with other treatments.
Row on the Pycnogenol (French maritime pine bark extract) page · PubMed 31637782 (opens PubMed)
- CGrade CBlood lipids · No difference
Meta-analysis · n 442 · 2014 · Patients in 7 controlled trials
Varied across trials · Varied
No significant change in total, LDL or HDL cholesterol or triglycerides.
Row on the Pycnogenol (French maritime pine bark extract) page · PubMed 24346156 (opens PubMed)