Phosphatidylserine and brain & focus
What 5 graded rows on phosphatidylserine agree on for brain & focus, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Phosphatidylserine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Phosphatidylserine page, with its PubMed record.
Your question
Phosphatidylserine and brain & focus
5 rows · 877 peopleSplit. 3 rows found an improvement, 1 found no difference and 1 had mixed results.
- CGrade C× 3
- DGrade D× 1
- ∅No effect× 1
- Rows
- 5
- Trials
- 5
- People
- 877
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 494 people (1993) and found an improvement. 1 row is graded No effect, our grade for adequately powered trials that found no effect.
Only the 3 rows that found an improvement name older adults and children or teens in their population.
1 row with mixed results is left out of this comparison.
The rows
3 improved · 1 no difference · 1 mixed- CGrade CMemory and behaviour in elderly people with cognitive decline · Improved
RCT · n 494 · 1993 · Adults aged 65–93 with moderate to severe cognitive decline, 23 Italian centres
300 mg/day · 6 months
Behaviour and memory test scores improved more than with placebo; 69 people dropped out, and PS was well tolerated.
Row on the Phosphatidylserine page · PubMed 8323999 (opens PubMed)
- CGrade CMemory in age-associated memory impairment · Improved
RCT · n 149 · 1991 · Older adults with age-associated memory impairment
100 mg three times a day · 12 weeks
Learning and memory test scores improved versus placebo, mainly in people who scored lowest at the start.
Row on the Phosphatidylserine page · PubMed 2027477 (opens PubMed)
- DGrade DADHD symptoms and short-term memory in children · Improved
RCT · n 36 · 2014 · Children aged 4–14 with ADHD not on drug treatment
200 mg/day · 2 months
ADHD symptom scores and short-term auditory memory improved versus placebo.
Row on the Phosphatidylserine page · PubMed 23495677 (opens PubMed)
- ∅No effectMemory and cognition with soy PS · No difference
RCT · n 120 · 2001 · Adults over 57 with age-associated memory impairment
300 or 600 mg/day · 12 weeks plus 3-week wash-out
Neither dose changed memory or other cognitive measures compared with placebo.
Row on the Phosphatidylserine page · PubMed 11842880 (opens PubMed)
- CGrade CMemory in older adults with memory complaints · Mixed
RCT · n 78 · 2010 · Japanese adults aged 50–69 with memory complaints
100 or 300 mg/day · 6 months
Scores rose similarly in all groups including placebo; in people with low starting scores, memory (mainly delayed verbal recall) rose with PS but not placebo.
Row on the Phosphatidylserine page · PubMed 21103034 (opens PubMed)