Phosphatidic Acid and muscle

What 6 graded rows on phosphatidic acid agree on for muscle, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Phosphatidic Acid page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Phosphatidic Acid page, with its PubMed record.

Your question

Muscle6

Supplement

Phosphatidic Acid Choose another

Phosphatidic Acid and muscle

6 rows · 121 people

Split. 2 rows found an improvement, 1 found no difference, 1 found a worse outcome and 2 had mixed results.

No difference, mixed or worse

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Red: a worse outcome. Outlined: mixed results.

Grade D× 6

Rows: 6
Trials: 6
People: 121

Where they differ

From the rows

When published

The best-graded row, grade D, is a randomized trial of 28 people (2016) and reported mixed results.

The row that found no difference is newer (2017) than the 2 rows that found an improvement (2014 to 2016).

2 rows with mixed results are left out of this comparison.

The rows

2 improved · 1 no difference · 1 worse · 2 mixed

Grade DLean mass, muscle size and strength with resistance training · Improved
RCT · n 28 · 2014 · Resistance-trained men, mean age 21
750 mg/day · 8 weeks of periodized training
Lean body mass (+2.4 kg), muscle cross-sectional area (+1.0 cm) and leg press strength (+51.9 kg) increased more than with placebo.
Row on the Phosphatidic Acid page · PubMed 24959196 (opens PubMed)
Grade DLean mass and strength with a PA-based blend · Improved
RCT · n 18 · 2016 · Strength-trained men on a monitored diet
Daily blend (PA amount not stated in the abstract) · 8 weeks of training (3 days/week)
Lean mass and leg- and bench-press 1RM rose more than with placebo; fat mass, thigh muscle, jump, agility, power and push-ups did not differ.
Row on the Phosphatidic Acid page · PubMed 27274715 (opens PubMed)
Grade DMuscle thickness and 1RM strength with resistance training · No difference
RCT · n 15 · 2017 · Resistance-trained men, mean age 23
750 mg/day · 8 weeks of supervised training (3 days/week)
Muscle thickness of four muscles and squat, deadlift and bench press 1RM improved in both groups with no difference between PA and placebo.
Row on the Phosphatidic Acid page · PubMed 28177725 (opens PubMed)
Grade DMuscle protein synthesis after resistance exercise in older men · Worse
RCT · n 16 · 2019 · Older men doing one-leg resistance exercise
750 mg single dose after exercise · Single session (5 hours of measurement)
Exercise raised myofibrillar protein synthesis above rest with placebo but not with phosphatidic acid, and anabolic signalling (p70S6K, rpS6, 4E-BP1, Akt) was lower with phosphatidic acid.
Row on the Phosphatidic Acid page · PubMed 29970319 (opens PubMed)
Grade DBody composition and leg strength at 250 or 375 mg/day · Mixed
RCT · n 28 · 2016 · Resistance-trained men
250 or 375 mg/day · 8 weeks of training
All groups gained lean mass, muscle size and strength with no significant group differences; magnitude-based inference rated PA as "likely" helpful for size and strength.
Row on the Phosphatidic Acid page · PubMed 27803633 (opens PubMed)
Grade DLean mass and squat strength with resistance training · Mixed
Pilot RCT · n 16 · 2012 · Resistance-trained men
750 mg/day · 8 weeks of training (4 days/week)
Lean mass rose 2.6% vs 0.1% and squat strength 12.7% vs 9.3%, but standard statistics showed no significant difference; magnitude-based inference rated the benefits "likely".
Row on the Phosphatidic Acid page · PubMed 23035701 (opens PubMed)

Read onRead the full evidenceThe full evidence chapter on its page, with every outcome and its sources.