Passionflower (Passiflora incarnata) and anxiety
What 5 graded rows on passionflower (passiflora incarnata) agree on for anxiety, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Passionflower (Passiflora incarnata) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Passionflower (Passiflora incarnata) page, with its PubMed record.
Your question
Passionflower (Passiflora incarnata) and anxiety
5 rows · 378 peopleSplit. 2 rows found an improvement, 1 found no difference and 2 had mixed results.
- DGrade D× 5
- Rows
- 5
- Trials
- 6
- People
- 378
- Pooled reviews may count some twice
Where they differ
From the rowsThe best-graded row, grade D, is a systematic review of 198 people (2007) and reported mixed results.
The row that found no difference is newer (2025) than the 2 rows that found an improvement (2008 to 2024).
2 rows with mixed results are left out of this comparison.
The rows
2 improved · 1 no difference · 2 mixed- DGrade DAnxiety before ambulatory surgery · Improved
RCT · n 60 · 2008 · Adults having outpatient surgery (Iran)
500 mg single dose, 90 minutes before surgery · Single dose
Anxiety scores were significantly lower than placebo (P < 0.001) with no difference in sedation, psychomotor recovery or discharge time.
Row on the Passionflower (Passiflora incarnata) page · PubMed 18499602 (opens PubMed)
- DGrade DAnxiety during third-molar extraction · Improved
RCT · n 54 · 2024 · Adults having wisdom-tooth extraction (three arms)
Single dose (amount not stated in abstract) · Single procedure
State anxiety fell from before to after surgery with passionflower and with valerian, but not with placebo (P = 0.129).
Row on the Passionflower (Passiflora incarnata) page · PubMed 38743126 (opens PubMed)
- DGrade DAnxiety during impacted third-molar extraction · No difference
RCT · n 30 · 2025 · Healthy patients aged 16–35 having impacted wisdom-tooth extraction (Brazil; three arms of 10)
Single dose 30 minutes before surgery (amount not stated in abstract) · Single procedure
Anxiety scores did not differ between passionflower, midazolam and placebo; salivary cortisol after surgery was lower with passionflower and midazolam than placebo, and diastolic blood pressure was higher with passionflower.
Row on the Passionflower (Passiflora incarnata) page · PubMed 41381570 (opens PubMed)
- DGrade DAnxiety disorders (systematic review) · Mixed
Systematic review, 2 studies · n 198 · 2007 · Adults with anxiety disorders in 2 RCTs
As used in each trial · 4 weeks
One trial found no difference from a benzodiazepine; dropout rates were similar. The reviewers judged the trials too few to permit conclusions.
Row on the Passionflower (Passiflora incarnata) page · PubMed 17253512 (opens PubMed)
- DGrade DGeneralized anxiety disorder symptoms · Mixed
RCT · n 36 · 2001 · Outpatients with DSM-IV generalized anxiety disorder (Iran)
45 drops/day (vs oxazepam 30 mg/day) · 4 weeks
Both groups improved with no significant difference at 4 weeks; oxazepam acted faster but caused more job-performance problems.
Row on the Passionflower (Passiflora incarnata) page · PubMed 11679026 (opens PubMed)