Nitrosigine (inositol-stabilized arginine silicate) and cognition
What 4 graded rows on nitrosigine (inositol-stabilized arginine silicate) agree on for cognition, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Nitrosigine (inositol-stabilized arginine silicate) page, reviewed Oct 17, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Nitrosigine (inositol-stabilized arginine silicate) page, with its PubMed record.
Your question
Nitrosigine (inositol-stabilized arginine silicate) and cognition
4 rows · 121 peopleThey agree: all 4 rows found an improvement.
- DGrade D× 4
- Rows
- 4
- Trials
- 4
- People
- 121
What the rows share
From the rowsThe best-graded row, grade D, is a randomized trial of 60 people (2019) and found an improvement.
The rows run from 16 to 60 people, published from 2016 to 2021: 4 single studies.
The rows
4 improved- DGrade DMood, energy and task accuracy in gamers over 7 days (with added inositol) · Improved
RCT · n 60 · 2019 · Healthy adults gaming at least 5 hours a week
Daily dose (amount not stated in the abstract) · 7 days
Self-rated energy rose, anger fell and Trail Making B errors fell versus placebo; adverse events were minimal and similar between groups.
Row on the Nitrosigine (inositol-stabilized arginine silicate) page · PubMed 31581523 (opens PubMed)
- DGrade DReaction time and working memory in gamers (with added inositol) · Improved
Crossover RCT · n 26 · 2021 · Experienced video gamers, 18 men and 8 women
1,600 mg single dose · Single dose before 1 hour of gaming
Several Sternberg working-memory reaction times were faster than with placebo after gaming; other tests were better maintained.
Row on the Nitrosigine (inositol-stabilized arginine silicate) page · PubMed 34836014 (opens PubMed)
- DGrade DMemory and overall cognition 60 minutes after one dose · Improved
Crossover RCT · n 19 · 2021 · Healthy young adults (mean age 21)
1.5 g single dose · Single dose per session
Total RBANS and immediate-memory scores improved versus dextrose placebo; other cognitive domains did not differ.
Row on the Nitrosigine (inositol-stabilized arginine silicate) page · PubMed 34959823 (opens PubMed)
- DGrade DComplex-task speed (Trail Making Test B) after 3 days · Improved
Crossover RCT · n 16 · 2016 · Healthy, minimally active men aged 18–35
1,500 mg/day · 3 days per period
TMT B time fell 33% versus placebo about 10 minutes after the first dose and 35% from baseline after 3 days. A separate 14-day crossover in 11 trained men found a 28% drop from baseline.
Row on the Nitrosigine (inositol-stabilized arginine silicate) page · PubMed 27869715 (opens PubMed)