Nattokinase and blood pressure

What 3 graded rows on nattokinase agree on for blood pressure, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Nattokinase page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Nattokinase page, with its PubMed record.

Supplement

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3 rows · 711 people

Mostly an improvement: 2 of 3 rows, and most of the people. 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade C, is a meta-analysis of 546 people (2023) and reported mixed results.

The rows run from 79 to 546 people, published from 2008 to 2023: 1 pooled review and 2 single studies.

2 improved · 1 mixed

Grade CBlood pressure in prehypertension or stage 1 hypertension · Improved
RCT · n 86 · 2008 · Adults 20–80 with untreated systolic BP 130–159 mmHg
2,000 FU/day · 8 weeks
Net changes versus placebo were −5.55 mmHg systolic and −2.84 mmHg diastolic (both p<0.05); plasma renin activity also fell.
Row on the Nattokinase page · PubMed 18971533 (opens PubMed)
Grade DBlood pressure in a North American hypertensive population · Improved
RCT · n 79 · 2016 · Adults with systolic BP ≥130 or diastolic ≥90 mmHg (North America)
100 mg/day · 8 weeks
Diastolic BP fell from 87 to 84 mmHg versus no change on placebo (p<0.05), with larger drops in men; systolic reductions were reported for both sexes.
Row on the Nattokinase page · PubMed 27785095 (opens PubMed)
Grade CBlood pressure, lipids and glucose · Mixed
Meta-analysis, 6 studies · n 546 · 2023 · Adults in 6 RCTs
Varied across trials · Varied across trials
Systolic BP fell 3.45 mmHg and diastolic 2.32 mmHg versus placebo, but total and LDL cholesterol rose slightly at lower doses and blood glucose rose 0.40 units; HDL fell at lower doses. No notable adverse events.
Row on the Nattokinase page · PubMed 39076715 (opens PubMed)