NADH and energy
What 4 graded rows on nadh agree on for energy, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the NADH page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the NADH page, with its PubMed record.
Your question
NADH and energy
4 rows · 383 peopleSplit. 2 rows found an improvement and 2 had mixed results.
- DGrade D× 4
- Rows
- 4
- Trials
- 4
- People
- 383
What the rows share
From the rowsThe best-graded row, grade D, is a randomized trial of 207 people (2021) and reported mixed results.
The rows run from 26 to 207 people, published from 1999 to 2021: 4 single studies.
The rows
2 improved · 2 mixed- DGrade DFatigue score with CoQ10 plus NADH · Improved
RCT · n 73 · 2015 · Adults with chronic fatigue syndrome in Spain
20 mg/day NADH (with 200 mg CoQ10) · 8 weeks
Fatigue impact scores fell more than with placebo, and blood-cell NAD+/NADH and ATP rose.
- DGrade DResponders on a fatigue symptom score · Improved
Crossover RCT · n 26 · 1999 · Adults with chronic fatigue syndrome
10 mg/day · 4 weeks per arm
8 of 26 (31%) responded to NADH versus 2 of 26 (8%) to placebo; no serious side effects.
- DGrade DCognitive fatigue and quality of life with CoQ10 plus NADH · Mixed
RCT · n 207 · 2021 · Adults with ME/CFS
20 mg/day NADH (with 200 mg CoQ10) · 12 weeks
Cognitive fatigue and quality of life improved from baseline in the supplement group; the abstract reports within-group changes rather than a clear difference from placebo.
- DGrade DFatigue, function and quality of life · Mixed
RCT · n 77 · 2010 · Adults with chronic fatigue syndrome
20 mg/day · 2 months
Most outcomes did not differ from placebo; anxiety scores and peak heart rate after an exercise test fell with NADH.