Mangosteen and mental health
What 2 graded rows on mangosteen agree on for mental health, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Mangosteen page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Mangosteen page, with its PubMed record.
Your question
Mangosteen and mental health
2 rows · 250 peopleSplit. 1 row found no difference and 1 had mixed results.
- CGrade C× 1
- ∅No effect× 1
- Rows
- 2
- Trials
- 2
- People
- 250
What the rows share
From the rowsThe best-graded row, grade C, is a randomized trial of 114 people (2025) and reported mixed results. 1 row is graded No effect, our grade for adequately powered trials that found no effect.
The rows run from 114 to 136 people, published from 2021 to 2025: 2 single studies.
The rows
1 no difference · 1 mixed- ∅No effectSchizophrenia symptom scores (PANSS) as an add-on to usual treatment · No difference
RCT · n 136 · 2021 · Adults with schizophrenia or schizoaffective disorder (Australia)
1,000 mg/day · 24 weeks
Both groups improved over time with no difference between mangosteen and placebo on any symptom, function or quality-of-life measure.
- CGrade CDepression scores (MADRS) in bipolar depression as an add-on to usual treatment · Mixed
RCT · n 114 · 2025 · Adults with bipolar I or II disorder and at least moderate depression (Australia)
1,000 mg/day (2 × 500 mg capsules) · 24 weeks, plus 4 weeks off treatment
Depression scores (MADRS, the main outcome) tracked placebo until week 20, so the overall group-by-time effect was not significant; by week 24 they had fallen more with mangosteen (13.8 vs 9.7 points, P = 0.037), and clinician-rated severity and social functioning were also better. These differences faded 4 weeks after stopping.