Magnesium glycinate and migraine

What 2 graded rows on magnesium glycinate agree on for migraine, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Magnesium glycinate page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Magnesium glycinate page, with its PubMed record.

Supplement

Magnesium glycinate Choose another

2 rows · 870 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a meta-analysis of 789 people (2016) and found an improvement.

The rows run from 81 to 789 people, published from 1996 to 2016: 1 pooled review and 1 single study.

2 improved

Grade CMigraine attack frequency · Improved
Meta-analysis, 10 studies · n 789 · 2016 · 10 RCTs of oral magnesium for migraine prophylaxis
Varied by trial · Varied by trial
Oral magnesium reduced migraine frequency (odds ratio 0.20) and intensity (OR 0.27) versus control; some included trials did not use adequate randomization. A 2012 AAN/AHS guideline rated magnesium 'probably effective' for prevention (Level B).
Row on the Magnesium glycinate page · PubMed 26752497 (opens PubMed)
Grade CMigraine attack frequency (citrate trial) · Improved
RCT · n 81 · 1996 · Adults 18–65 with migraine, mean 3.6 attacks per month
600 mg/day magnesium · 12 weeks
In weeks 9–12, attack frequency fell 41.6% with magnesium versus 15.8% with placebo (p < 0.05). Diarrhea in 18.6% and gastric irritation in 4.7%.
Row on the Magnesium glycinate page · PubMed 8792038 (opens PubMed)