Magnesium chloride and mood

What 3 graded rows on magnesium chloride agree on for mood, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Magnesium chloride page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Magnesium chloride page, with its PubMed record.

Supplement

Magnesium chloride Choose another

3 rows · 209 people

They agree: all 3 rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a crossover trial of 126 people (2017) and found an improvement.

The rows run from 23 to 126 people, published from 2008 to 2024: 3 single studies.

3 improved

Grade CMild-to-moderate depression and anxiety symptoms · Improved
Crossover RCT · n 126 · 2017 · Adults in US primary care with PHQ-9 scores of 5 to 19 (mean age 52)
248 mg elemental magnesium/day · 6 weeks active vs 6 weeks no treatment (crossover)
Net improvement of 6.0 points on PHQ-9 and 4.5 points on GAD-7 versus the no-treatment period; 112 participants gave analysable data.
Row on the Magnesium chloride page · PubMed 28654669 (opens PubMed)
Grade DDepressive symptoms after COVID-19 in adults with low magnesium and vitamin D · Improved
RCT · n 60 · 2024 · Adults with long-COVID, low serum magnesium, vitamin D deficiency and mild-to-moderate depressive symptoms (Mexico)
1,300 mg/day magnesium chloride (salt weight as reported) with 4,000 IU vitamin D · 4 months
73% vs 34.5% reached a Beck Depression Inventory score under 11 (p = 0.006). Mild adverse events in 20% vs 10%.
Row on the Magnesium chloride page · PubMed 39846976 (opens PubMed)
Grade DDepression in older adults with type 2 diabetes and low magnesium · Improved
RCT · n 23 · 2008 · Older adults with type 2 diabetes, low serum magnesium and new depression (Mexico)
50 ml of 5% magnesium chloride solution daily (450 mg elemental magnesium) · 12 weeks
Depression scores improved similarly with magnesium chloride and with imipramine 50 mg (11.4 vs 10.9 points at the end, no significant difference).
Row on the Magnesium chloride page · PubMed 19271419 (opens PubMed)