Lumbrokinase (Earthworm) and stroke
What 3 graded rows on lumbrokinase (earthworm) agree on for stroke, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Lumbrokinase (Earthworm) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Lumbrokinase (Earthworm) page, with its PubMed record.
Your question
Lumbrokinase (Earthworm) and stroke
3 rows · 541 peopleThey agree: all 3 rows found an improvement.
- DGrade D× 3
- Rows
- 3
- Trials
- 3
- People
- 541
What the rows share
From the rowsThe best-graded row, grade D, is a randomized trial of 310 people (2013) and found an improvement.
The rows run from 51 to 310 people, published from 2000 to 2021: 3 single studies.
The rows
3 improved- DGrade DVascular events over 1 year after ischemic stroke · Improved
RCT · n 310 · 2013 · Hospitalized ischemic stroke patients (192 lumbrokinase, 118 control), all on standard stroke treatment
Oral capsules (dose not stated in the abstract) · 12 months
Total vascular events were 2.08% vs 6.78% and cerebral vascular events 1.04% vs 5.93% (P < 0.05); fibrinogen, carotid wall thickness and plaque measures also favored lumbrokinase.
Row on the Lumbrokinase (Earthworm) page · PubMed 24229674 (opens PubMed)
- DGrade DStroke disability scores (NIHSS, Barthel Index) at 30 days · Improved
RCT · n 180 · 2021 · Adults with acute ischemic stroke at an Indonesian referral centre, all on aspirin 100 mg, atorvastatin and vitamin B12
Three times daily (amount not stated in the abstract) · 30 days
NIHSS improved more with DLBS1033 at discharge (−5.57 vs −3.64) and day 30 (−6.62 vs −5.14), as did Barthel Index scores; good functional outcome (mRS <2) at day 30 did not differ significantly (86.7% vs 80%). No clinically significant product-related adverse events.
Row on the Lumbrokinase (Earthworm) page · PubMed 33927846 (opens PubMed)
- DGrade DStroke scores and clotting markers in cerebral infarction · Improved
RCT · n 51 · 2000 · Patients with cerebral infarction (31 lumbrokinase, 20 control)
Not stated in the abstract · Not stated in the abstract
Stroke scores fell in both groups, more with lumbrokinase; KPTT lengthened, t-PA activity and D-dimer rose and fibrinogen fell, while PT and PAI did not change.
Row on the Lumbrokinase (Earthworm) page · PubMed 11321442 (opens PubMed)