Lactase enzyme and infant colic
What 2 graded rows on lactase enzyme agree on for infant colic, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Lactase enzyme page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Lactase enzyme page, with its PubMed record.
Your question
Lactase enzyme and infant colic
2 rows · 553 peopleSplit. 1 row found an improvement and 1 found no difference.
- CGrade C× 2
- Rows
- 2
- Trials
- 2
- At least: a review without a trial count
- People
- 553
- Pooled reviews may count some twice
Where they differ
From the rowsThe best-graded row, grade C, is a systematic review of 391 people (2024) and found no difference.
The row that found no difference was larger: 391 people, against 162 people for the row that found an improvement.
The row that found no difference is a pooled review of several trials; the row that found an improvement is a single study.
The row that found an improvement ran longer (4 weeks) than the row that found no difference (7 days).
The row that found no difference is newer (2024) than the row that found an improvement (2022).
The rows
1 improved · 1 no difference- CGrade CCrying or fussing time and days with colic · Improved
RCT · n 162 · 2022 · Infants under 5 months with colic (India)
5 drops in breast milk or formula four times a day · 4 weeks
Crying or fussing fell to about 90 vs 179 minutes a day with placebo, and colic days were fewer; adverse events were similar.
Row on the Lactase enzyme page · PubMed 35922776 (opens PubMed)
- CGrade CCrying and fussing time in infant colic · No difference
Systematic review · n 391 · 2024 · Infants under 6 months with colic in 5 randomized trials
Varied by trial · 1–4 weeks
Three trials reported less crying, but a meta-analysis of two found no difference in crying or fussing time after 1 week; risk of bias was high in three of the five trials.
Row on the Lactase enzyme page · PubMed 38426798 (opens PubMed)