L-arginine and sexual function
What 2 graded rows on l-arginine agree on for sexual function, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the L-arginine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the L-arginine page, with its PubMed record.
Your question
L-arginine and sexual function
2 rows · 913 peopleThey agree: both rows found an improvement.
- CGrade C× 2
- Rows
- 2
- Trials
- 11
- At least: a review without a trial count
- People
- 913
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade C, is a meta-analysis of 540 people (2019) and found an improvement.
The rows run from 373 to 540 people, published from 2019 to 2021: 2 pooled reviews and 0 single studies.
The rows
2 improved- CGrade CErectile function in mild to moderate ED · Improved
Meta-analysis, 10 studies · n 540 · 2019 · Men with mild to moderate erectile dysfunction in 10 RCTs
1,500–5,000 mg/day · Varied across trials
Improvement was more likely than with placebo or no treatment (odds ratio 3.37); side effects were more common (8.3% vs 2.3%) but none severe. Several trials combined arginine with other substances.
- CGrade CErectile function with L-arginine plus a PDE5 inhibitor · Improved
Meta-analysis · n 373 · 2021 · Men with erectile dysfunction in 4 randomized trials
Daily oral L-arginine (dose not given in the abstract) · Varied by trial
The combination improved sexual function scores and total testosterone more than either drug alone, without more adverse events than a PDE5 inhibitor alone; a PDE5 inhibitor alone worked better than L-arginine alone.