Isomaltulose (Palatinose) and blood sugar
What 3 graded rows on isomaltulose (palatinose) agree on for blood sugar, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Isomaltulose (Palatinose) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Isomaltulose (Palatinose) page, with its PubMed record.
Your question
Isomaltulose (Palatinose) and blood sugar
3 rows · 643 peopleMostly an improvement: 2 of 3 rows, and most of the people. 1 found no difference.
- BGrade B× 2
- ∅No effect× 1
- Rows
- 3
- Trials
- 3
- At least: a review without a trial count
- People
- 643
- Pooled reviews may count some twice
Where they differ
From the rowsThe best-graded row, grade B, is a meta-analysis of 367 people (2025) and found an improvement. 1 row is graded No effect, our grade for adequately powered trials that found no effect.
The 2 rows that found an improvement were larger: a median of 271 people, against 101 people for the row that found no difference.
The 2 rows that found an improvement are pooled reviews of several trials; the row that found no difference is a single study.
The 2 rows that found an improvement are newer (2022 to 2025) than the row that found no difference (2012).
The rows
2 improved · 1 no difference- BGrade BPost-meal glucose vs sucrose in people with and without diabetes · Improved
Meta-analysis · n 367 · 2025 · People with diabetes and healthy people (10 studies)
As in the included studies · Single-meal tests
Plasma glucose at 60 minutes was lower than with sucrose (mean difference −7.99), though the authors note the clinical effect may be modest and results varied widely.
Row on the Isomaltulose (Palatinose) page · PubMed 40507211 (opens PubMed)
- BGrade BBlood glucose and insulin after a drink vs sucrose or other sugars · Improved
Meta-analysis · n 175 · 2022 · Adults who were healthy or had type 2 diabetes, impaired glucose tolerance or hypertension (11 RCTs)
Single test drinks after an overnight fast · 2-hour tests
Moderate-certainty evidence for a smaller glucose rise than sucrose at 30 minutes; low-certainty evidence for a lower but longer glucose curve and a smaller insulin response.
Row on the Isomaltulose (Palatinose) page · PubMed 35595510 (opens PubMed)
- ∅No effectHbA1c after replacing sucrose for 12 weeks (type 2 diabetes) · No difference
RCT · n 101 · 2012 · Adults with type 2 diabetes eating their habitual diet
50 g/day in place of sucrose · 12 weeks
HbA1c did not differ from the sucrose group (7.24% vs 7.39%); triglycerides were significantly lower with isomaltulose.
Row on the Isomaltulose (Palatinose) page · PubMed 22492584 (opens PubMed)