Iodine (potassium iodide, kelp) and thyroid function

What 2 graded rows on iodine (potassium iodide, kelp) agree on for thyroid function, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Iodine (potassium iodide, kelp) page, with its PubMed record.

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Iodine (potassium iodide, kelp) and thyroid function

2 rows · 2,186 people

They agree: both rows found an improvement.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade C× 2
Rows
2
Trials
11
People
2,186
Pooled reviews may count some twice

What the rows share

From the rows

The best-graded row, grade C, is a meta-analysis of 1,922 people (2026) and found an improvement.

The rows run from 264 to 1,922 people, published in 2026: 2 pooled reviews and 0 single studies.

The rows

2 improved
  1. Grade CTSH and thyroglobulin in iodine-deficient pregnancy · Improved

    Meta-analysis, 10 studies · n 1,922 · 2026 · Iodine-deficient pregnant women (urinary iodine below 150 µg/L) in randomized trials and prospective cohorts (TSH analysis: 10 studies)

    Varied; TSH fell more with 200–300 μg/day · Varied; started in different trimesters

    TSH fell (SMD −0.14, 95% CI −0.23 to −0.05) and thyroglobulin fell (SMD −0.22, 95% CI −0.32 to −0.13); free T3 and free T4 did not change significantly. Thyroid volume was larger in European studies and when supplements continued after birth.

    Row on the Iodine (potassium iodide, kelp) page · PubMed 42359139 (opens PubMed)

  2. Grade CHypothyroidism in children in iodine-deficient areas · Improved

    Systematic review · n 264 · 2026 · Children in randomized trials of iodine vs placebo (hypothyroidism analysis: 1 study)

    Varied: 150 mcg daily for 28 weeks in one trial; single doses of 100–490 mg in the others · Follow-up 3 to 22 months

    Iodine likely reduced hypothyroidism a lot compared with placebo (RR 0.03, 95% CI 0.00 to 0.23), moderate-certainty evidence. The effect on goitre was very uncertain.

    Row on the Iodine (potassium iodide, kelp) page · PubMed 42720098 (opens PubMed)

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