Green-lipped mussel (Perna canaliculus) and knee osteoarthritis

What 2 graded rows on green-lipped mussel (perna canaliculus) agree on for knee osteoarthritis, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Green-lipped mussel (Perna canaliculus) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Green-lipped mussel (Perna canaliculus) page, with its PubMed record.

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Knee osteoarthritis2

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Green-lipped mussel (Perna canaliculus) and knee osteoarthritis

2 rows · 220 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

Grade C× 2

Rows: 2
Trials: 2
People: 220

What the rows share

From the rows

The best-graded row, grade C, is a randomized trial of 120 people (2024) and reported mixed results.

The rows run from 100 to 120 people, published from 2024 to 2026: 2 single studies.

The rows

1 improved · 1 mixed

Grade CKnee pain and function (WOMAC, VAS) · Improved
RCT · n 100 · 2026 · Adults aged 40–75 with symptomatic radiographic knee osteoarthritis in Korea
1,000 mg/day · 12 weeks
WOMAC total improved more than placebo per protocol (−3.66, p=0.032) but not significantly by intention to treat (p=0.061); VAS pain fell 19.9 mm more (p<0.001). CRP and ESR unchanged; no meaningful safety concerns.
Row on the Green-lipped mussel (Perna canaliculus) page · PubMed 42464085 (opens PubMed)
Grade CKnee osteoarthritis symptoms, pain and physical performance · Mixed
RCT · n 120 · 2024 · Adults aged 55–80 with early signs of knee osteoarthritis in New Zealand
3 g/day · 6 months
VAS symptom score fell more than with placebo (median −28.1% vs 0.0%, P=0.03). The KOOS sport and recreation score, intermittent pain and the fast-walk test showed only non-significant trends (P=0.08–0.09), and the share of people with a clinically important improvement did not differ between groups. Mild indigestion or reflux affected 8 people on mussel powder and 2 on placebo.
Row on the Green-lipped mussel (Perna canaliculus) page · PubMed 38645882 (opens PubMed)

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