Glycine and psychiatric add-on
What 2 graded rows on glycine agree on for psychiatric add-on, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Glycine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Glycine page, with its PubMed record.
Your question
Glycine and psychiatric add-on
2 rows · 44 peopleSplit. 1 row found an improvement and 1 found no difference.
- DGrade D× 2
- Rows
- 2
- Trials
- 2
- People
- 44
Where they differ
From the rowsThe best-graded row, grade D, is a randomized trial of 27 people (2000) and found no difference.
The row that found no difference ran longer (8 weeks) than the row that found an improvement (6 weeks).
The row that found an improvement is newer (2004) than the row that found no difference (2000).
The rows
1 improved · 1 no difference- DGrade DNegative symptoms added to antipsychotics · Improved
Crossover RCT · n 17 · 2004 · People with schizophrenia on olanzapine or risperidone
0.8 g/kg/day · 6 weeks per period
Negative symptoms fell by about 23% versus placebo; glycine was well tolerated under supervision.
- DGrade DSchizophrenia symptoms when added to clozapine · No difference
RCT · n 27 · 2000 · Adults with schizophrenia taking clozapine
60 g/day · 8 weeks
No significant change in positive or negative symptoms or cognition versus placebo; no one worsened clinically.