Eggshell membrane and knee arthritis
What 5 graded rows on eggshell membrane agree on for knee arthritis, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Eggshell membrane page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Eggshell membrane page, with its PubMed record.
Your question
Eggshell membrane and knee arthritis
5 rows · 910 peopleSplit. 3 rows found an improvement and 2 had mixed results.
- CGrade C× 5
- Rows
- 5
- Trials
- 9
- People
- 910
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade C, is a meta-analysis of 530 people (2024) and found an improvement.
The rows run from 67 to 530 people, published from 2009 to 2024: 1 pooled review and 4 single studies.
The rows
3 improved · 2 mixed- CGrade CKnee osteoarthritis pain and function (pooled) · Improved
Meta-analysis, 5 studies · n 530 · 2024 · Adults with knee osteoarthritis in 5 placebo-controlled trials (7 reviewed)
300–500 mg/day · 8 weeks to 90 days across pooled trials
Total WOMAC score improved (SMD −0.34, 95% CI −0.56 to −0.13), as did the pain (SMD −0.23) and function (SMD −0.33) subscales; stiffness and VAS pain did not differ significantly from placebo.
Row on the Eggshell membrane page · PubMed 39203777 (opens PubMed)
- CGrade CKnee pain and quadriceps strength in osteoarthritis · Improved
RCT · n 75 · 2022 · Adults with knee osteoarthritis (functional grade I-III) and chronic knee pain, Spain; mean age about 38
300 mg or 500 mg once daily · 8 weeks
Pain fell in all groups including placebo; the 500 mg group had a significantly larger pain reduction than placebo and gained knee strength on isometric and isokinetic tests. No product-related adverse events.
Row on the Eggshell membrane page · PubMed 35684140 (opens PubMed)
- CGrade CKnee osteoarthritis pain and stiffness · Improved
RCT · n 67 · 2009 · Adults with knee osteoarthritis (multicenter, USA)
500 mg once daily · 8 weeks
Pain and stiffness responses improved vs placebo at 10, 30 and 60 days; WOMAC function and total scores were not significantly better, though they trended that way. No serious adverse events.
Row on the Eggshell membrane page · PubMed 19340512 (opens PubMed)
- CGrade CKnee osteoarthritis pain and daily-life function · Mixed
RCT · n 150 · 2021 · Adults aged 40-75 with knee osteoarthritis
300 mg once daily · 12 weeks
The primary 0-10 pain rating at 6 weeks fell similarly with membrane and placebo. KOOS Pain and Daily Life scores improved more with membrane from week 1 and stayed better through week 12.
Row on the Eggshell membrane page · PubMed 32633648 (opens PubMed)
- CGrade CKnee function, walking distance and stiffness in osteoarthritis · Mixed
RCT · n 88 · 2019 · Adults with knee osteoarthritis, USA
450 mg once daily · 12 weeks
Without normalization, WOMAC, 6-minute walk and range of motion did not improve vs placebo. After normalizing to baseline, stiffness improved by day 5 and walking distance by week 12, most in the worst performers. Found safe.
Row on the Eggshell membrane page · PubMed 31381494 (opens PubMed)