Echinacea and colds

What 3 graded rows on echinacea agree on for colds, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Echinacea page, with its PubMed record.

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Echinacea and colds

3 rows · 10,258 people

Mostly an improvement: 2 of 3 rows, and most of the people. 1 had mixed results.

Mixed
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.
  • Grade C× 3
Rows
3
Trials
39
People
10,258
Pooled reviews may count some twice

What the rows share

From the rows

The best-graded row, grade C, is a systematic review of 4,631 people (2014) and reported mixed results.

The rows run from 2,458 to 4,631 people, published from 2014 to 2025: 3 pooled reviews and 0 single studies.

The rows

2 improved · 1 mixed
  1. Grade CRespiratory infections in children · Improved

    Meta-analysis, 9 studies · n 3,169 · 2025 · Children in 9 RCTs of upper respiratory infections and otitis media (1,518 echinacea, 1,651 placebo)

    Varied across trials · Varied across trials

    Fewer infections (RR 0.81), slightly shorter illness (SMD −0.19) and less antibiotic use (RR 0.18); fewer ear-infection episodes (RR 0.56) but no shorter ear infections. Adverse events, mostly mild, were more frequent (RR 1.38).

    Row on the Echinacea page · PubMed 40311928 (opens PubMed)

  2. Grade CRepeat respiratory infections · Improved

    Meta-analysis, 6 studies · n 2,458 · 2015 · Generally healthy children and adults in 6 selected high-quality trials

    Varied across trials · Varied across trials

    Recurrent respiratory infections were less likely (RR 0.65) and complications such as pneumonia and ear infection were less frequent (RR 0.50).

    Row on the Echinacea page · PubMed 25784510 (opens PubMed)

  3. Grade CCommon colds · Mixed

    Systematic review, 24 studies · n 4,631 · 2014 · Children and adults in 24 double-blind trials (33 comparisons)

    Varied across trials · Varied across trials

    None of 12 prevention comparisons was significant alone (post hoc pooling suggested a 10–20% relative reduction); only 1 of 7 treatment trials shortened colds.

    Row on the Echinacea page · PubMed 24554461 (opens PubMed)

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