Diosmin and leg vein symptoms
What 2 graded rows on diosmin agree on for leg vein symptoms, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Diosmin page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Diosmin page, with its PubMed record.
Your question
Diosmin and leg vein symptoms
2 rows · 1,764 peopleThey agree: both rows found an improvement.
- BGrade B× 1
- CGrade C× 1
- Rows
- 2
- Trials
- 8
- People
- 1,764
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade B, is a meta-analysis of 1,692 people (2018) and found an improvement.
The rows run from 72 to 1,692 people, published from 2018 to 2021: 1 pooled review and 1 single study.
The rows
2 improved- BGrade BLeg pain, heaviness, swelling and quality of life in chronic venous disease (MPFF) · Improved
Meta-analysis, 7 studies · n 1,692 · 2018 · Patients with chronic venous disease in 7 randomized double-blind placebo-controlled trials
As given in each trial · Varied by trial
MPFF reduced leg pain (RR 0.53), heaviness (RR 0.35), feeling of swelling (RR 0.39), cramps (RR 0.51) and functional discomfort vs placebo; as continuous scores pain fell slightly (SMD -0.25) and feeling of swelling more (SMD -0.99). Ankle circumference, leg redness, skin changes and quality of life (SMD -0.21) also improved.
- CGrade CLeg swelling, pain and quality of life in chronic venous disease · Improved
RCT · n 72 · 2021 · Adults with chronic venous disease, CEAP class C2-C4, Italy (multicenter)
450 mg once daily · 8 weeks
Leg edema fell vs placebo from week 4 (p < 0.001); pain (VAS) improved at week 8 (p < 0.05); Global Index Score and Venous Clinical Severity Score improved at week 8 (p < 0.001). No treatment-related side effects. 72 completed.