Digestive enzymes and indigestion

What 2 graded rows on digestive enzymes agree on for indigestion, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Digestive enzymes page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Digestive enzymes page, with its PubMed record.

Supplement

Digestive enzymes Choose another

2 rows · 160 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a randomized trial of 120 people (2023) and found an improvement.

The rows run from 40 to 120 people, published from 2018 to 2023: 2 single studies.

2 improved

Grade CFunctional dyspepsia symptoms and quality of life · Improved
RCT · n 120 · 2023 · Adults aged 18-59 with functional dyspepsia
2 capsules a day (200 mg blend each) · 2 months
Nepean Dyspepsia Index scores, pain severity (VAS) and sleep quality (PSQI) improved vs placebo, without side effects.
Row on the Digestive enzymes page · PubMed 37976892 (opens PubMed)
Grade CFunctional dyspepsia symptoms · Improved
RCT · n 40 · 2018 · Adults with functional dyspepsia
50 mg three times a day · 60 days
All efficacy scales (Leeds, Nepean, VAS, CGI-S, Glasgow) improved more than placebo (P .0401 to .0033); no product-related adverse events or lab changes.
Row on the Digestive enzymes page · PubMed 30156436 (opens PubMed)