Conjugated Linoleic Acid (CLA) and insulin sensitivity
What 2 graded rows on conjugated linoleic acid (cla) agree on for insulin sensitivity, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Conjugated Linoleic Acid (CLA) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Conjugated Linoleic Acid (CLA) page, with its PubMed record.
Your question
Conjugated Linoleic Acid (CLA) and insulin sensitivity
2 rows · 178 peopleSplit. 1 row found no difference and 1 found a worse outcome.
- CGrade C× 2
- Rows
- 2
- Trials
- 2
- People
- 178
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 118 people (2007) and found no difference.
The row that found no difference ran longer (6 months) than the row that found a worse outcome (3 months).
Only the row that found a worse outcome names men in its population.
The row that found no difference is newer (2007) than the row that found a worse outcome (2002).
The rows
1 no difference · 1 worse- CGrade CInsulin sensitivity (clamp test) · No difference
RCT · n 118 · 2007 · Adults with overweight or obesity
Dose not stated in the abstract · 6 months
CLA did not change insulin sensitivity measured by clamp in the 49-person clamp subgroup (41 completed both clamps), or fasting measures of insulin resistance, compared with olive oil placebo.
Row on the Conjugated Linoleic Acid (CLA) page · PubMed 17031391 (opens PubMed)
- CGrade CInsulin resistance (an adverse effect) · Worse
RCT · n 60 · 2002 · Abdominally obese men with metabolic syndrome
3.4 g daily · 12 weeks
Purified t10,c12-CLA raised insulin resistance by 19% and blood glucose by 4% and lowered HDL by 4% versus placebo; the isomer mixture did not change glucose metabolism or body composition but lowered HDL by 2%.
Row on the Conjugated Linoleic Acid (CLA) page · PubMed 12196420 (opens PubMed)