Chlorella and cholesterol

What 4 graded rows on chlorella agree on for cholesterol, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Chlorella page, with its PubMed record.

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Chlorella and cholesterol

4 rows · 1,433 people

They agree: all 4 rows found an improvement.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade B× 2
  • Grade C× 2
Rows
4
Trials
31
People
1,433
Pooled reviews may count some twice

What the rows share

From the rows

The best-graded row, grade B, is a meta-analysis of 797 people (2018) and found an improvement.

The rows run from 34 to 797 people, published from 2014 to 2022: 2 pooled reviews and 2 single studies.

The rows

4 improved
  1. Grade BCholesterol, blood pressure and fasting glucose · Improved

    Meta-analysis, 19 studies · n 797 · 2018 · Adults of varied health status (19 RCTs)

    Varied; effects clearer above 4 g/day in subgroup analysis · Varied; effects clearer at 8 weeks or longer

    Total cholesterol fell 9.1 mg/dL, LDL 8.3 mg/dL, systolic BP 4.5 mm Hg, diastolic BP 1.6 mm Hg and fasting glucose 4.2 mg/dL; triglycerides, HDL and BMI did not change.

    Row on the Chlorella page · PubMed 29037431 (opens PubMed)

  2. Grade BBlood lipids (Chlorella vulgaris) · Improved

    Meta-analysis, 10 studies · n 539 · 2022 · Adults (10 RCTs)

    Varied; LDL effect seen at doses up to 1,500 mg/day in dose-response analysis · Varied

    Total cholesterol fell 7.5 mg/dL and LDL 7.7 mg/dL; triglycerides and HDL did not change. Only 4 trials had low risk of bias.

    Row on the Chlorella page · PubMed 35331862 (opens PubMed)

  3. Grade CSerum lipids in mildly high cholesterol · Improved

    RCT · n 63 · 2014 · Adults with mild hypercholesterolaemia

    5 g/day · 4 weeks (after 2-week lead-in)

    Versus placebo, total cholesterol (−1.6% vs 0.03%) and triglycerides (−10.3% vs +11.9%) fell, with lower VLDL and apolipoprotein B and large rises in serum lutein/zeaxanthin and α-carotene.

    Row on the Chlorella page · PubMed 24920270 (opens PubMed)

  4. Grade CSerum cholesterol during a dietary cholesterol challenge · Improved

    RCT · n 34 · 2016 · Healthy adults eating three eggs (510 mg cholesterol) daily

    5 g/day · 4 weeks

    Total cholesterol rose 3.5% versus 9.8% on placebo and LDL 1.7% versus 14.3%.

    Row on the Chlorella page · PubMed 27177615 (opens PubMed)

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