Cetylated Fatty Acids (Celadrin) and joint pain

What 2 graded rows on cetylated fatty acids (celadrin) agree on for joint pain, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Cetylated Fatty Acids (Celadrin) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Cetylated Fatty Acids (Celadrin) page, with its PubMed record.

Supplement

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2 rows · 590 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade D, is an observational study of 562 people (2025) and found an improvement.

The rows run from 28 to 562 people, published from 2005 to 2025: 2 single studies.

2 improved

Grade DSub-acute or chronic musculoskeletal pain and NSAID use · Improved
Observational · n 562 · 2025 · Italian adults (mean age 49) prescribed oral CFA by 120 primary care physicians
Not stated in the abstract · 30 days
Overall pain score fell 38.84% and interference with daily activities 44.53%; NSAID dose and frequency fell 19.7%, and 55.2% rated NSAID-related heartburn as improved.
Row on the Cetylated Fatty Acids (Celadrin) page · PubMed 40462886 (opens PubMed)
Grade DPain and function with a cream containing menthol · Improved
Open-label trial · n 28 · 2005 · Adults with knee osteoarthritis (10) or elbow (8) or wrist (10) arthritis pain
Applied twice a day · 1 week
Knee patients improved stair climbing and up-and-go performance by about 12% with less pain; elbow and wrist patients improved local muscular endurance. Grip strength did not change.
Row on the Cetylated Fatty Acids (Celadrin) page · PubMed 15903393 (opens PubMed)