Castor Oil and labour induction

What 5 graded rows on castor oil agree on for labour induction, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Castor Oil page, with its PubMed record.

Your question

Castor Oil and labour induction

5 rows · 1,496 people

Split. 2 rows found an improvement, 1 found no difference and 2 had mixed results.

No difference or mixed
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.
  • Grade C× 4
  • No effect× 1
Rows
5
Trials
14
People
1,496
Pooled reviews may count some twice

Where they differ

From the rows
Study designWhen published

The best-graded row, grade C, is a meta-analysis of 902 people (2022) and reported mixed results. 1 row is graded No effect, our grade for adequately powered trials that found no effect.

The row that found no difference is a pooled review of several trials; the 2 rows that found an improvement are single studies.

The 2 rows that found an improvement are newer (2022 to 2026) than the row that found no difference (2013).

2 rows with mixed results are left out of this comparison.

The rows

2 improved · 1 no difference · 2 mixed
  1. Grade CLabour within 48 hours at 40 to 41 weeks · Improved

    RCT · n 210 · 2026 · Women at 40+0 to 41+0 weeks in two Enugu hospitals (Nigeria); 70 per arm

    Single dose (amount not stated in the abstract) · Single dose

    Labour within 48 hours in 52.9% with castor oil vs 24.3% with expectant care (OR 3.50); membrane sweeping 62.9%, not significantly different from castor oil.

    Row on the Castor Oil page · PubMed 42671437 (opens PubMed)

  2. Grade CLabour onset within 24 hours after a previous caesarean · Improved

    RCT · n 70 · 2022 · Women with one previous caesarean attempting vaginal birth (Egypt)

    60 ml once · Single dose

    Labour started within 24 hours in 45.7% with castor oil vs 8.5% with placebo; successful vaginal birth 65.7% vs 48.5%.

    Row on the Castor Oil page · PubMed 34886746 (opens PubMed)

  3. No effectCaesarean birth and newborn outcomes after castor oil for labour · No difference

    Meta-analysis, 3 studies · n 233 · 2013 · Women in the third trimester in 3 trials

    Single dose · Single dose

    No difference in caesarean section (RR 2.04, 95% CI 0.92 to 4.55), instrumental delivery, meconium-stained liquor or low Apgar score; all women who drank castor oil felt nauseous (RR 59.92).

    Row on the Castor Oil page · PubMed 23881775 (opens PubMed)

  4. Grade CLabour onset and cervical ripening late in pregnancy · Mixed

    Meta-analysis, 8 studies · n 902 · 2022 · Pregnant women at or past term in 8 studies

    Single oral dose (amounts varied by study) · Single dose

    Labour induction odds ratio 11.67 (95% CI 3.34 to 40.81) and higher Bishop scores (SMD 1.64) versus control; the reported Bishop-score confidence interval (1.67 to 2.11) does not contain its own point estimate.

    Row on the Castor Oil page · PubMed 35837141 (opens PubMed)

  5. Grade CEntering active labour within 48 hours, post-date pregnancy · Mixed

    RCT · n 81 · 2018 · Low-risk post-date singleton pregnancies, outpatient

    60 ml once · Single dose

    Benefit only in women who had given birth before (hazard ratios 2.78 to 3.29 at 24 to 48 hours); no effect in first-time mothers and no difference in complications.

    Row on the Castor Oil page · PubMed 28750937 (opens PubMed)

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