Carnosine and inflammation

What 2 graded rows on carnosine agree on for inflammation, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Carnosine page, with its PubMed record.

Your question

Supplement
Carnosine Choose another

Carnosine and inflammation

2 rows · 391 people

Split. 1 row found an improvement and 1 found no difference.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade C× 1
  • Grade D× 1
Rows
2
Trials
10
People
391
Pooled reviews may count some twice

Where they differ

From the rows
Trial sizeStudy designGrade

The best-graded row, grade C, is a meta-analysis of 350 people (2024) and found an improvement.

The row that found an improvement was larger: 350 people, against 41 people for the row that found no difference.

The row that found an improvement is a pooled review of several trials; the row that found no difference is a single study.

The best grade is C among the row that found an improvement, and D among the row that found no difference.

The rows

1 improved · 1 no difference
  1. Grade CInflammation and oxidative-stress markers (pooled) · Improved

    Meta-analysis, 9 studies · n 350 · 2024 · Participants in 9 trials

    Varied across trials · Varied across trials

    CRP fell by 0.97 mg/L, TNF-α by 3.60 pg/mL and malondialdehyde by 0.34 µmol/L, and catalase rose, versus placebo; IL-6, adiponectin, glutathione, SOD and total antioxidant capacity did not change.

    Row on the Carnosine page · PubMed 38086332 (opens PubMed)

  2. Grade DInflammatory markers and adipokines · No difference

    RCT · n 41 · 2024 · Adults with prediabetes or well-controlled type 2 diabetes (completers)

    2 g/day · 14 weeks

    Changes in CRP, IL-6, TNF-α, adiponectin, leptin and other markers did not differ from placebo.

    Row on the Carnosine page · PubMed 39599686 (opens PubMed)

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