Cannabinol (CBN) and sleep quality

What 3 graded rows on cannabinol (cbn) agree on for sleep quality, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Cannabinol (CBN) page, with its PubMed record.

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Cannabinol (CBN) and sleep quality

3 rows · 3,106 people

Split. 1 row found an improvement, 1 found no difference and 1 had mixed results.

No difference or mixed
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.
  • Grade C× 3
Rows
3
Trials
3
People
3,106

Where they differ

From the rows

The best-graded row, grade C, is a randomized trial of 1,793 people (2024) and found no difference.

By our six checks (size, design, length, who was studied, year and grade), the two sides do not differ cleanly. The dose and how each outcome was measured are in the rows below. 1 row with mixed results is left out of this comparison.

The rows

1 improved · 1 no difference · 1 mixed
  1. Grade CSelf-rated sleep disturbance · Improved

    RCT · n 1,020 · 2024 · Adults with sleep disturbance in a remote trial

    25, 50 or 100 mg · Not stated in the abstract

    All three CBN doses and melatonin improved PROMIS sleep disturbance scores vs placebo, with no difference between CBN and melatonin; 100 mg also lowered stress, and side effects did not differ from placebo.

    Row on the Cannabinol (CBN) page · PubMed 39204082 (opens PubMed)

  2. Grade CSleep disturbance with CBN added to CBD · No difference

    RCT · n 1,793 · 2024 · Adults with symptoms of sleep disturbance

    15 mg CBN with 15 mg CBD · 4 weeks

    All formulations improved sleep from baseline, but adding CBN (with or without CBC) gave no extra benefit over 15 mg CBD alone.

    Row on the Cannabinol (CBN) page · PubMed 37162192 (opens PubMed)

  3. Grade CSleep quality and awakenings in poor sleepers · Mixed

    RCT · n 293 · 2024 · Adults aged 18 to 55 rating their sleep as poor or very poor

    20 mg CBN at night · 7 nights

    Overall sleep quality was not significantly better (OR 2.26, p = 0.082), but 20 mg CBN reduced awakenings (p = 0.025) and overall sleep disturbance (p = 0.023); sleep onset, WASO and daytime fatigue did not change, and adding CBD did not help.

    Row on the Cannabinol (CBN) page · PubMed 37796540 (opens PubMed)

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