Cannabidiol (CBD) and pain

What 2 graded rows on cannabidiol (cbd) agree on for pain, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Cannabidiol (CBD) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Cannabidiol (CBD) page, with its PubMed record.

Supplement

Cannabidiol (CBD) Choose another

2 rows · 408 people

Split. 1 row found no difference and 1 found a worse outcome.

No difference or worse

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Red: a worse outcome.

From the rows

Study designHow longGrade

The best-graded row, grade B, is a randomized trial of 200 people (2026) and found a worse outcome.

The row that found no difference is a pooled review of several trials; the row that found a worse outcome is a single study.

The row that found a worse outcome ran longer (6 months) than the row that found no difference (2 weeks).

The best grade is B among the row that found a worse outcome, and C among the row that found no difference.

1 no difference · 1 worse

Grade CPain relief in chronic nerve (neuropathic) pain, CBD-dominant medicines · No difference
Meta-analysis, 5 studies · n 208 · 2026 · Adults with chronic neuropathic pain (5 RCTs of CBD-dominant medicines)
Varied across trials · 2 to 26 weeks across the review
No clear effect on the share of people with at least 50% pain relief (risk difference −0.08, 95% CI −0.20 to 0.05; very low certainty); withdrawals and serious side effects did not clearly differ from placebo.
Row on the Cannabidiol (CBD) page · PubMed 41548880 (opens PubMed)
Grade BPain intensity in fibromyalgia · Worse
RCT · n 200 · 2026 · Adults with fibromyalgia from a specialist clinic (Denmark)
50 mg/day · 24 weeks
Pain fell 0.4 points with CBD and 1.1 points with placebo on a 0–10 scale, a between-group difference of −0.7 points (95% CI −1.2 to −0.25) favouring placebo; side effects were mild and similar between groups.
Row on the Cannabidiol (CBD) page · PubMed 40846590 (opens PubMed)