Butcher's broom and leg veins

What 3 graded rows on butcher's broom agree on for leg veins, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Butcher's broom page, with its PubMed record.

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Butcher's broom and leg veins

3 rows · 11,113 people

They agree: all 3 rows found an improvement.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade B× 1
  • Grade C× 2
Rows
3
Trials
12
At least: a review without a trial count
People
11,113
Pooled reviews may count some twice

What the rows share

From the rows

The best-graded row, grade B, is a meta-analysis of 719 people (2017) and found an improvement.

The rows run from 148 to 10,246 people, published from 2002 to 2017: 2 pooled reviews and 1 single study.

The rows

3 improved
  1. Grade BLeg heaviness, pain and swelling in chronic venous disease (Ruscus products) · Improved

    Meta-analysis, 10 studies · n 719 · 2017 · Adults with chronic venous disease in double-blind placebo-controlled trials

    As used in each trial · Varied

    Versus placebo, Ruscus products reduced leg pain (RR 0.35, NNT 5), heaviness (RR 0.26, NNT 2.4), paresthesia and global symptoms, and reduced ankle circumference (SMD −0.74) and leg or foot volume (SMD −0.61).

    Row on the Butcher's broom page · PubMed 28225220 (opens PubMed)

  2. Grade CVenous symptom severity (Ruscus + hesperidin methyl chalcone + vitamin C) · Improved

    Meta-analysis · n 10,246 · 2003 · Adults with chronic venous insufficiency (31 studies, including 6 single-arm)

    As used in each study · Varied

    On a 0–3 scale, pain fell 0.44, heaviness 0.53, cramps 0.26 and paresthesia 0.29 points more than placebo; venous capacity also fell. Edema score and calf and ankle circumference did not fall significantly.

    Row on the Butcher's broom page · PubMed 14612852 (opens PubMed)

  3. Grade CLower-leg volume in chronic venous insufficiency (single-ingredient extract) · Improved

    RCT · n 148 · 2002 · Women aged 30–89 with chronic venous insufficiency (CEAP 3–4)

    Daily dose per the German monograph (amount not stated in the abstract) · 12 weeks

    Leg volume fell 20.5 mL more than placebo at 12 weeks, with smaller ankle and calf circumferences and less heaviness and tension. Tolerability was rated good to very good.

    Row on the Butcher's broom page · PubMed 12040966 (opens PubMed)

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