Betaine HCl and stomach acid

What 2 graded rows on betaine hcl agree on for stomach acid, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Betaine HCl page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Betaine HCl page, with its PubMed record.

Supplement

Betaine HCl Choose another

2 rows · 15 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade D, is a crossover trial of 9 people (2019) and reported mixed results.

The rows run from 6 to 9 people, published from 2013 to 2019: 2 single studies.

1 improved · 1 mixed

Grade DGastric pH after acid suppression (healthy volunteers) · Improved
PK study · n 6 · 2013 · Healthy volunteers with rabeprazole-induced low stomach acid (USA)
1,500 mg single dose · Single dose, pH monitored for 2 hours
Gastric pH fell by 4.5 units (5.2 to 0.6) within 30 minutes, reaching pH below 3 in about 6 minutes; pH stayed below 3 for about 73 minutes. Well tolerated.
Row on the Betaine HCl page · PubMed 23980906 (opens PubMed)
Grade DRe-acidifying the stomach after a meal · Mixed
Crossover RCT · n 9 · 2019 · Healthy adults (USA)
1,500, 3,000 or 4,500 mg after food · Single doses (4-period open-label crossover)
Food raised gastric pH (peak about 3.2) and pH returned to baseline in about 50 minutes without acid; only 4,500 mg brought it back faster (about 17 minutes). Overall pH-time curves did not differ significantly between treatments.
Row on the Betaine HCl page · PubMed 31485804 (opens PubMed)