Benfotiamine and nerves

What 3 graded rows on benfotiamine agree on for nerves, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Benfotiamine page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Benfotiamine page, with its PubMed record.

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Nerves3

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Benfotiamine and nerves

3 rows · 289 people

Split. 1 row found an improvement and 2 found no difference.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

Grade C× 1
No effect× 2

Rows: 3
Trials: 3
People: 289

Where they differ

From the rows

Trial sizeHow longWhen published

The best-graded row, grade C, is a randomized trial of 165 people (2008) and found an improvement. 2 rows are graded No effect, our grade for adequately powered trials that found no effect.

The row that found an improvement was larger: 165 people, against a median of 62 people for the 2 rows that found no difference.

The 2 rows that found no difference ran longer (12 months to 2 years) than the row that found an improvement (6 weeks).

The 2 rows that found no difference are newer (2012 to 2026) than the row that found an improvement (2008).

The rows

1 improved · 2 no difference

No effectPeripheral nerve function in type 1 diabetes · No difference
RCT · n 67 · 2012 · Adults with type 1 diabetes
300 mg/day · 24 months
Blood thiamine rose markedly, but nerve function and inflammatory markers did not change versus placebo.
Row on the Benfotiamine page · PubMed 22446172 (opens PubMed)
No effectCorneal nerve fibre length in type 2 diabetes · No difference
RCT · n 57 · 2026 · Adults with type 2 diabetes and mild to moderate symptomatic polyneuropathy
300 mg twice daily · 12 months
Corneal nerve fibre length did not change versus placebo; treatment was well tolerated.
Row on the Benfotiamine page · PubMed 41571333 (opens PubMed)
Grade CNeuropathy symptom score in diabetes · Improved
RCT · n 165 · 2008 · Adults with symmetrical distal diabetic polyneuropathy
300 or 600 mg/day · 6 weeks
The Neuropathy Symptom Score improved more than with placebo; the Total Symptom Score did not differ.
Row on the Benfotiamine page · PubMed 18473286 (opens PubMed)

Read onRead the full evidenceThe full evidence chapter on its page, with every outcome and its sources.