Baikal Skullcap (Scutellaria baicalensis) and stress & mood

What 2 graded rows on baikal skullcap (scutellaria baicalensis) agree on for stress & mood, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Baikal Skullcap (Scutellaria baicalensis) page, with its PubMed record.

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Baikal Skullcap (Scutellaria baicalensis) and stress & mood

2 rows · 215 people

They agree: both rows found an improvement.

No difference
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside.
  • Grade D× 2
Rows
2
Trials
2
People
215

What the rows share

From the rows

The best-graded row, grade D, is a randomized trial of 180 people (2025) and found an improvement.

The rows run from 35 to 180 people, published in 2025: 2 single studies.

The rows

2 improved
  1. Grade DMild-to-moderate depressive symptoms · Improved

    RCT · n 180 · 2025 · Adults with mild-to-moderate depressive symptoms, split across four arms (scutellaria, saffron, both, placebo)

    Not stated in the abstract · 6 weeks

    The scutellaria extract alone had a positive effect on mood regulation (the abstract gives no figures); the scutellaria-saffron combination improved depressive and anxious symptoms and emotional well-being vs placebo. Adverse effects were minimal.

    Row on the Baikal Skullcap (Scutellaria baicalensis) page · PubMed 40077679 (opens PubMed)

  2. Grade DMood, anxiety and cognition under stress · Improved

    Crossover RCT · n 35 · 2025 · Subjectively stressed but healthy adults aged 18–75 (43 enrolled, 35 analysed)

    Two tablets (component amounts not stated in the abstract) · 15 days

    Chronic use reduced total mood disturbance, anger/hostility and trait anxiety; working memory improved during a multitasking stressor. Cognitive effects were less consistent without the stressor. No serious adverse effects.

    Row on the Baikal Skullcap (Scutellaria baicalensis) page · PubMed 41194549 (opens PubMed)

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