Bacopa monnieri and cognition

What 4 graded rows on bacopa monnieri agree on for cognition, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Bacopa monnieri page, with its PubMed record.

Your question

Supplement
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Bacopa monnieri and cognition

4 rows · 735 people

Split. 2 rows found an improvement, 1 found no difference and 1 had mixed results.

No difference or mixed
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.
  • Grade C× 2
  • Grade D× 1
  • No effect× 1
Rows
4
Trials
12
People
735
Pooled reviews may count some twice

Where they differ

From the rows
Trial sizeStudy designWho was studiedWhen published

The best-graded row, grade C, is a meta-analysis of 518 people (2014) and found an improvement. 1 row is graded No effect, our grade for adequately powered trials that found no effect.

The 2 rows that found an improvement were larger: a median of 286 people, against 101 people for the row that found no difference.

Only the 2 rows that found an improvement include pooled reviews of several trials (1 of 2); the row that found no difference is a single study.

Only the 2 rows that found an improvement name older adults in their population.

The row that found no difference is newer (2025) than the 2 rows that found an improvement (2008 to 2014).

1 row with mixed results is left out of this comparison.

The rows

2 improved · 1 no difference · 1 mixed
  1. Grade CAttention speed and reaction time · Improved

    Meta-analysis, 9 studies · n 518 · 2014 · Adults in 9 RCTs of standardised extracts for ≥12 weeks

    Varied across trials · 12 weeks or longer

    Cognition improved versus placebo, particularly speed of attention and choice reaction time.

    Row on the Bacopa monnieri page · PubMed 24252493 (opens PubMed)

  2. Grade CDelayed word recall and attention in older adults · Improved

    RCT · n 54 · 2008 · Adults 65+ without dementia

    300 mg/day · 12 weeks

    Delayed word recall and Stroop scores improved versus placebo; depression and anxiety scores fell.

    Row on the Bacopa monnieri page · PubMed 18611150 (opens PubMed)

  3. No effectVerbal learning and memory in midlife · No difference

    RCT · n 101 · 2025 · Adults aged 40–70 with self-reported memory and attention problems

    300 mg/day · 12 weeks

    No between-group differences in the primary cognitive outcomes.

    Row on the Bacopa monnieri page · PubMed 41091332 (opens PubMed)

  4. Grade DCognition and sleep in mild cognitive impairment · Mixed

    RCT · n 62 · 2024 · Adults with mild cognitive impairment (Iranian university trial)

    160 mg extract pill (frequency not stated in the abstract) · 2 months

    Attention improved vs placebo at 1 month (P = 0.033) and 2 months (P = 0.004), and verbal fluency at 2 months; the abstract reports the overall cognitive score both as unchanged and as better at 2 months (P = 0.029). Sleep quality did not change.

    Row on the Bacopa monnieri page · PubMed 38538390 (opens PubMed)

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