L-Alanine and rehydration
What 2 graded rows on l-alanine agree on for rehydration, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the L-Alanine page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the L-Alanine page, with its PubMed record.
Your question
L-Alanine and rehydration
2 rows · 226 peopleSplit. 1 row found an improvement and 1 found no difference.
- DGrade D× 2
- Rows
- 2
- Trials
- 2
- People
- 226
Where they differ
From the rowsThe best-graded row, grade D, is a randomized trial of 129 people (1991) and found no difference.
Only the row that found no difference names children or teens in its population.
The row that found no difference is newer (1991) than the row that found an improvement (1989).
The rows
1 improved · 1 no difference- DGrade DStool output with alanine-glucose rehydration solution in severe diarrhea · Improved
RCT · n 97 · 1989 · Males aged 6–59 with severe dehydration from cholera or E. coli diarrhea, treated in hospital
Concentration not stated in the abstract · Until diarrhea stopped
Median 24-hour stool output fell from 309 to 196 mL/kg, and 2 versus 18 patients needed unscheduled IV fluids.
- DGrade DDuration of diarrhea in children with alanine rehydration solution · No difference
RCT · n 129 · 1991 · Boys aged 3–48 months with acute non-cholera diarrhea and mild-moderate dehydration
Offered at 120 mL/kg for 6 hours, then to replace stool losses · Until recovery
Urine output in the first 6 hours was higher, but duration of diarrhea, solution intake and stool output did not differ significantly from standard WHO solution.