Methylliberine (Dynamine)
Also called Dynamine, methyl liberine, Dynamine methylliberine.
Best grade D across 4 graded outcomes Other Last checked
The short answer
From 8 sourcesMethylliberine is a stimulant-type purine alkaloid sold as Dynamine. In one 25-person crossover trial, 100 mg raised self-rated energy, mood and concentration over three hours but did not change cognitive test scores. A 4-week trial in 125 young adults found no clinically meaningful safety changes. Every cited human study except a 2026 food-effect study was funded by Compound Solutions, which sells Dynamine.
Every graded outcome on this page
4 rows · line = participants- DGrade DHeart rate, blood pressure, QTc and blood safety markers over 4 weeksSafetyn 125
- DGrade DVigilance reaction time with a caffeine-methylliberine-theacrine blendAlertnessn 48
- DGrade DSelf-rated energy, concentration, motivation and moodEnergy and moodn 25
- DGrade DCognitive test performance (Stroop, Trail Making B)Cognitionn 25
Key facts
- Energy and mood
- 100 mg improved self-rated energy, concentration, motivation and mood vs placebo over 3 hours in 25 healthy adults2
- Cognition
- The same trial found negligible effects on Stroop and Trail Making B test scores2
- Safety
- 100 or 150 mg daily for 4 weeks, alone or with theacrine, produced no clinically significant changes in heart rate, blood pressure, QTc or blood tests in 125 young adults1
- Funding
- Compound Solutions, which sells Dynamine, funded every cited human study except the 2026 food-effect study, including the blend trial and the 2020 pharmacokinetic study; the mood trial's research centre is owned by a methylliberine patent holder12356
- Food effect
- A high-fat meal significantly lowered methylliberine exposure compared with fasting in 12 volunteers6
What it is
Methylliberine is a caffeine-like purine alkaloid found in small amounts in coffee plants and sold in synthetic form as Dynamine.
How it works
ProposedMethylliberine is a methylurate, chemically related to caffeine and theacrine, found in some Coffea species. It is marketed as having caffeine-like stimulant effects; its receptor targets in people have not been established, and the human research so far measures feelings and safety markers rather than mechanism.512
Forms, side by side
2 forms named in our sources. The rest show what our data holds, and say plainly where it holds nothing yet.
Methylliberine (Dynamine) forms compared
2 forms| 2 forms | Synthetic methylliberine (Dynamine) | Blends with caffeine and theacrine |
|---|---|---|
| Absorption in people | Detectable in saliva soon after an oral dose; exposure fell significantly after a high-fat meal compared with fasting.65 | Plasma levels of all three compounds were measured after a combined dose in 12 people.5 |
| GI tolerance | No adverse events in a 25-person crossover trial; no clinically significant safety-marker changes over 4 weeks in 125 young adults.21 | A caffeine-containing blend raised systolic blood pressure vs placebo in one trial.3 |
| Studied for | Energy, mood, focus, safety markers | Alertness and reaction time |
- Synthetic methylliberine (Dynamine)
- Absorption in people
- Detectable in saliva soon after an oral dose; exposure fell significantly after a high-fat meal compared with fasting.65
- GI tolerance
- No adverse events in a 25-person crossover trial; no clinically significant safety-marker changes over 4 weeks in 125 young adults.21
- Studied for
- Energy, mood, focus, safety markers
- Blends with caffeine and theacrine
What the human research says
Human trials only, one row per outcome. The form line shows what each trial actually tested. Grades follow our evidence-grading policy.
Trial map
4 graded outcomes, largest study first4 graded outcomes: 2 improved, 2 no effect. The largest, a 2020 randomized trial of 125 people on heart rate, blood pressure, QTc and blood safety markers over 4 weeks, found no effect.
Bar: the ages a study enrolled (running to the edge when it states no upper or lower limit). Dot: only a mean age, counted as near your age within 5 years. Tick: the mean age inside a range.
1Heart rate, blood pressure, QTc and blood safety markers over 4 weeks: no effect, mean age 23
3Self-rated energy, concentration, motivation and mood: improved, mean age 33.5
4Cognitive test performance (Stroop, Trail Making B): no effect, mean age 33.5
2Vigilance reaction time with a caffeine-methylliberine-theacrine blend: improved, ages not stated
1Heart rate, blood pressure, QTc and blood safety markers over 4 weeks
No effect · Grade D · RCT, 125 people, 2020
Healthy young men and women, mean age 23 (USA)
Dose, result and source| Outcome | Found | People | Study | Who was studied |
|---|---|---|---|---|
| Heart rate, blood pressure, QTc and blood safety markers over 4 weeks | No effect | 125 | Grade D · RCT, 2020 | Healthy young men and women, mean age 23 (USA) |
| Vigilance reaction time with a caffeine-methylliberine-theacrine blend | Improved | 48 | Grade D · RCT, 2022 | Tactical personnel (USA) |
| Self-rated energy, concentration, motivation and mood | Improved | 25 | Grade D · Crossover RCT, 2023 | Healthy men and women, mean age 33.5 years (USA) |
| Cognitive test performance (Stroop, Trail Making B) | No effect | 25 | Grade D · Crossover RCT, 2023 | Healthy men and women, mean age 33.5 years (USA) |
Every graded row
4 rowsShowing 4 of 4 outcomes. Human trials only.
DGrade DHeart rate, blood pressure, QTc and blood safety markers over 4 weeksSafetyNo clinically significant changesRCT
n 125 · 2020
No effect Small time effects were seen in several markers regardless of group, but no clinically significant changes occurred in any group.
- Design
- RCT, n = 125, 2020
- Population
- Healthy young men and women, mean age 23 (USA)
- Form
- Methylliberine (Dynamine) alone or with theacrine (TeaCrine), vs placebo
- Dose
- 100 or 150 mg/day methylliberine, alone or with 25-50 mg theacrine
- Duration
- 4 weeks
- Source
- Reference 1 · PubMed 32121218 (opens PubMed)
DGrade DVigilance reaction time with a caffeine-methylliberine-theacrine blendAlertnessFaster vigilance RT (blend)RCT
n 48 · 2022
Improved Vigilance reaction time improved with both the blend and 300 mg caffeine but not placebo; no effect on movement or marksmanship; systolic blood pressure was higher than placebo with both the blend and caffeine.
- Design
- RCT, n = 48, 2022
- Population
- Tactical personnel (USA)
- Form
- 150 mg caffeine + 100 mg methylliberine + 50 mg theacrine vs 300 mg caffeine vs placebo
- Dose
- Single dose
- Duration
- 150-minute protocol
- Source
- Reference 3 · PubMed 36016763 (opens PubMed)
DGrade DSelf-rated energy, concentration, motivation and moodEnergy and moodHigher self-rated energy and moodCrossover RCT
n 25 · 2023
Improved Methylliberine improved energy, sustained energy and mood more than placebo at 1 h and 3 h, and concentration, well-being and ability to tolerate stress more than placebo at 3 h (p ≤ 0.050). No adverse events were reported.
- Design
- Crossover RCT, n = 25, 2023
- Population
- Healthy men and women, mean age 33.5 years (USA)
- Form
- Methylliberine (Dynamine) vs placebo
- Dose
- 100 mg/day for 3 days, then a 100 mg test dose on day 4
- Duration
- 4 days per condition, 1-week washout
- Source
- Reference 2 · PubMed 37960163 (opens PubMed)
DGrade DCognitive test performance (Stroop, Trail Making B)CognitionNo changeCrossover RCT
n 25 · 2023
No effect Methylliberine had a negligible influence on cognitive function and vital signs (p > 0.050).
- Design
- Crossover RCT, n = 25, 2023
- Population
- Healthy men and women, mean age 33.5 years (USA)
- Form
- Methylliberine (Dynamine) vs placebo
- Dose
- 100 mg/day for 3 days, then a 100 mg test dose on day 4
- Duration
- 4 days per condition, 1-week washout
- Source
- Reference 2 · PubMed 37960163 (opens PubMed)
What the numbers add up to
Each point is worked out from the data and the sources numbered on this page, with the arithmetic shown under it. It adds no new data and is not medical advice.
Feels different, tests the same
In the only single-ingredient efficacy trial, methylliberine changed how people said they felt but not how they scored on cognitive tests.2
Supplier-linked evidence
Studied doses
Doses used in research, shown against the official limits. They describe the studies, not a recommendation for you.
Studied doses in research, not advice. These are amounts used in research, not personal advice. Your clinician or pharmacist can say what fits you.
Doses studied in human trials
Interactions and safety
Published interactions only: each row cites a source. No row means none was found in our sources, not that a combination is safe.
What Methylliberine meets
2 cited rows 3 tested togetherMedicines 1
Supplements and foods 2
- Drug label or FDA notice
- Measured in a human study
- Tested together in a graded trial
Choose a medicine or supplement above to read its cited rows here.
Also cited: 3 tested together
MAO inhibitors (MAOIs)
Drug labelDrug label or FDA notice
MAO inhibitors (MAOIs), for example Phenelzine (Nardil), tranylcypromine, isocarboxazid: The Nardil label warns that excessive caffeine may cause hypertensive reactions with this MAOI. Methylliberine is caffeine-like and usually sold alongside caffeine, so the same caution applies by analogy; it has not been studied with MAOIs.
Source 7, Parke-Davis Div of Pfizer Inc (DailyMed) (2025)
CaffeineCaffeine page
RCTMeasured in a human study
Caffeine and other stimulants, for example Coffee, pre-workout and energy products: A blend of 150 mg caffeine, 100 mg methylliberine and 50 mg theacrine raised systolic blood pressure compared with placebo. Methylliberine is usually sold in stimulant blends, so total stimulant load adds up.
Source 3, J Int Soc Sports Nutr (2022)
Tested together
Vigilance reaction time with a caffeine-methylliberine-theacrine blend. Graded on the Methylliberine page; tested together is not a claim that they work better together.
TheacrineTheacrine page
Tested together
Heart rate, blood pressure, QTc and blood safety markers over 4 weeks. Graded on the Methylliberine page; tested together is not a claim that they work better together.
Tested together
Vigilance reaction time with a caffeine-methylliberine-theacrine blend. Graded on the Methylliberine page; tested together is not a claim that they work better together.
Interactions
2 agents| Agent | What the source says | Evidence |
|---|---|---|
| Medicines1 | ||
| MAO inhibitors (MAOIs)e.g. Phenelzine (Nardil), tranylcypromine, isocarboxazid | The Nardil label warns that excessive caffeine may cause hypertensive reactions with this MAOI. Methylliberine is caffeine-like and usually sold alongside caffeine, so the same caution applies by analogy; it has not been studied with MAOIs.7 | Drug label |
| Other supplements1 | ||
| Caffeine and other stimulantse.g. Coffee, pre-workout and energy products | A blend of 150 mg caffeine, 100 mg methylliberine and 50 mg theacrine raised systolic blood pressure compared with placebo. Methylliberine is usually sold in stimulant blends, so total stimulant load adds up.3 | RCT |
Check with what you take
Kept on this device onlyAdd what you take. We list every interaction our evidence profiles cite between Methylliberine and your picks, and between your picks.
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Add a supplement or medicine you take to check it against Methylliberine.
Starting from one medicine? The interaction checker rates how serious each pair is, on a curated list of 19 entries for 11 medicines. This cabinet has no severity rating: it lists every interaction row our supplement pages cite.
Who should be careful
5 groups- People with high blood pressure, heart rhythm problems or stimulant sensitivity
- The human trials enrolled healthy adults only, and a caffeine-containing blend raised systolic blood pressure. Safety in people with heart conditions has not been studied.13
- Pregnancy, breastfeeding and under-18s
- No trial included pregnant or breastfeeding women or teenagers, so there are no safety data for them.12
- Long-term use
- The longest human study lasted 4 weeks. In a 90-day rat study, the highest dose affected body weight and sexual organs in males, effects still present after a 28-day recovery period.14
- People taking MAO inhibitors
- The phenelzine (Nardil) label warns that excessive caffeine may cause hypertensive reactions. Methylliberine is caffeine-like and usually comes in caffeine blends, so the same caution applies by analogy; no study has tested it with MAOIs.73
- Drug interactions
- No published human drug-interaction studies of methylliberine were found.1
How to read the label
What to check on the Supplement Facts panel.
How to read the label
3 checksCheck the full stimulant load
Methylliberine is usually one ingredient in a blend. Add up caffeine and theacrine on the label too; the only blend trial used 150 mg caffeine alongside it.3
Frequently asked questions
Short answers to common questions; the numbers link to the sources below.
Common questions
7 answersDoes methylliberine work for energy?
In one 25-person crossover trial, 100 mg raised self-rated energy, mood and concentration over 3 hours, but cognitive test scores did not change.2
Is methylliberine safe?
A 4-week trial in 125 healthy young adults found no clinically significant changes at 100-150 mg a day. Longer-term and higher-risk groups have not been studied.1
How much methylliberine was studied?
Is methylliberine safe in pregnancy, or with medicines?
Is methylliberine the same as theacrine?
What is methylliberine?
Sources
8 sources: trial abstracts, NIH fact sheets and reference databases. Numbers in the text link here.
Sources cited on this page
8 sources- 1Safety of Short-Term Supplementation with Methylliberine (Dynamine(®)) Alone and in Combination with TeaCrine(®) in Young Adults.RCT Nutrients, 2020 · PMID 32121218
- 2Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women.Crossover RCT Nutrients, 2023 · PMID 37960163
- 3Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial.RCT J Int Soc Sports Nutr, 2022 · PMID 36016763
- 4A Toxicological Evaluation of Methylliberine (Dynamine®).Animal study J Toxicol, 2019 · PMID 31911801
- 5Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for characterizing caffeine, methylliberine, and theacrine pharmacokinetics in humans.PK study J Chromatogr B Analyt Technol Biomed Life Sci, 2020 · PMID 32829142
- 6Applicability of methylliberine as a salivary marker under postprandial conditions.PK study Int J Pharm X, 2026 · PMID 42370028
- 7NARDIL (phenelzine sulfate) tablets: prescribing informationLabel Parke-Davis Div of Pfizer Inc (DailyMed), 2025 · dailymed.nlm.nih.gov
- 821 CFR 101.36: Nutrition labeling of dietary supplements (proprietary blends, paragraph c)Guideline Electronic Code of Federal Regulations, 2026 · ecfr.gov
What changed
Every dated change to this page: what changed, who made it and why.
Change log
3 entries| Date | Change | Who and why |
|---|---|---|
| label guide, FAQ | Added a proprietary-blend step to the label guide (21 CFR 101.36(c), read on eCFR) and two FAQs (dose studied; pregnancy and interactions). PubMed search found no new methylliberine-only human trials; evidence rows unchanged. Fact-checked against the sources; corrected: the dose FAQ now notes the single-dose caffeine combination trial. | Writer: Kymata Health EditorialTrigger: A–Z page audit |
| all | Initial editorial evidence review (first draft). Every PMID checked against NCBI E-utilities esummary (titles and years taken from the record, none retracted) and the abstract read for each cited row. Studied doses are reported as research doses, not dosing advice. | Writer: Kymata Health EditorialTrigger: new page |
| key facts, evidence, interactions, who should avoid, FAQ | Review fixes: the 2022 blend trial (PMID 36016763) was funded by Compound Solutions, not independent; funding text now says every cited human study except the 2026 food-effect study (no external funding) was funded by Compound Solutions, including PMID 32829142 (Europe PMC grant list). Added an MAOI caution by analogy to caffeine, citing the Nardil label on DailyMed. | Writer: Kymata Health EditorialTrigger: adversarial review |
Supplement & Nutrient Encyclopedia. Educational information only; it is not medical advice and does not replace a clinician. Dietary supplements are not intended to diagnose, treat, cure or prevent any disease. Statements about supplements have not been evaluated by the FDA.