Khavinson BioregulatorTarget: OvariesReproductive

Zhenoluten

Ovary Extract Bioregulator · Ovarian Cytomax · Женолутен

Zhenoluten is the Cytomax female-reproductive complex. Ovagen is not the ovary cytogen on the official NPCRIZ poster - Ovagen is sold as a liver cytogen. The name Ovagen is the most damaging false friend in this catalog.

Not FDA-approved - research chemical

Quick answer

What it is: Zhenoluten is the Cytomax female-reproductive complex.

Class and target: Cytomax (natural peptide complex) · Female reproductive system (ovary-focused Cytomax)

Typical research dose: 1-2 capsules/day

Dosing details ↓What it is & the evidence on The Bioregulator Atlas →

Research summary, not medical advice.

Reviewed by Kymata Health Editorial Team
Last updated: August 2026Evidence: Low3 peer-reviewed citations
Typical research dose
1-2 capsules/day
Frequency
1-2× daily for 10-30 day cycles
Half-life
Mixture (variable)
Common vials
N/A (oral)
CAS
N/A (biological extract)
Molecular weight
Mixture (<10 kDa)

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Longevity / aging3.5/10

    Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.

  • Sexual / hormonal3.5/10

    Reproductive organ map. Not TRT and not an oncology protocol.

Compound card

Sequence
Female reproductive system (ovary-focused Cytomax) peptide complex (mixture, not a single CAS)
Class
Khavinson Cytomax capsule complex (Female reproductive system (ovary-focused Cytomax))
Formula
Polypeptide extract (Ovarian tissue <10 kDa)
Status
Not FDA-approved · research use

How it works

Zhenoluten (A-15) is a Cytomax natural polypeptide extract from the ovarian tissue of young calves, targeting human granulosa cells, theca cells, and ovarian stromal cells to restore age-silenced gene expression governing estradiol synthesis, FSH receptor sensitivity, and follicular development. Female ovarian aging follows a more abrupt trajectory than any other organ system: from age 35–38, ovarian reserve declines measurably; from 45–50, the follicular pool is largely depleted and the hypothalamic-pituitary-ovarian (HPO) axis loses its negative feedback anchor as estradiol production collapses, causing FSH to surge and triggering perimenopause and menopause.

Zhenoluten delivers short peptide signals (<10 kDa) from bovine ovarian tissue. These peptides enter granulosa and theca cell nuclei to reactivate transcription of: CYP19A1 (aromatase - the enzyme converting androgens to estradiol in granulosa cells), StAR (steroidogenic acute regulatory protein, the rate-limiting step in progesterone biosynthesis in theca cells), FSH receptor (FSHR) - allowing granulosa cells to better respond to pituitary FSH during late folliculogenesis, and AMH (anti-Müllerian hormone, a marker of ovarian reserve). Critically, Zhenoluten does not provide exogenous estrogen or progesterone - it works upstream at the gene regulation level.

In Khavinson's female reproductive longevity system, Zhenoluten (A-15, ovarian) is paired with Thyreogen (A-2, thyroid) since thyroid hormones are essential co-regulators of ovarian steroidogenesis - subclinical hypothyroidism exacerbates ovarian aging and menstrual irregularity. The full female hormonal stack adds Endoluten (A-8, pineal/melatonin) since circadian disruption strongly impairs HPO axis function via melatonin's direct effect on GnRH pulsatility.

Source: PMID: 11713572

Khavinson map

Canonical 41
Class
Cytomax (natural peptide complex)
Organ
Female reproductive system (ovary-focused Cytomax)
Target
Ovaries
System
Reproductive
Sequence
Mixture / not a single CAS
Pair
Name trap: Ovagen on NPCRIZ is the liver cytogen (EDL), not an ovary peptide
Женолутен

Used in bioregulator stacks

Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.

The Khavinson school

Zhenoluten is filed here as cytomax (natural peptide complex), targeting the female reproductive system (ovary-focused cytomax). Khavinson's St. Petersburg group moved from organ extracts (Cytamins) to capsule complexes (Cytomaxes) to synthetic short peptides (Cytogens); most of the evidence comes from that one group, with little independent Western replication.

Read the full background, the proposed epigenetic mechanism, the literature limits, and how we count the canonical 41 on the Khavinson bioregulators index.

History of this molecule

Someone in a Western warehouse looked at “Ovagen” and wrote “ovaries” on a spreadsheet. The Cytomed cytogen list says Ovagen - liver. Zhenoluten is the actual female-reproductive Cytomax. If you came here from a blog that pairs Ovagen with ovaries, you were reading a mistranslation that we are not going to repeat.

The Khavinson ovary/uterus logic is aging reproductive tissue and the peptide signals that keep granulosa/theca identity. It is not HRT, not FSH, not clomiphene, not progesterone.

Livagen (KEDA) is the other liver synthetic; Svetinorm is liver Cytomax. Keep female reproductive and hepatic aisles labeled like a grown-up.

Caveats

Female reproductive Cytomax is not a US dietary-supplement monograph and not a drug. The tissue-extract model means lot-to-lot composition is a fingerprint, not a single CAS number. Some English-language bottles carry a “V2” label. Vita Peptides, for example, labels its own house line V2 (15 mg per capsule vs 10 mg in V1). No study compares V1 and V2 outcomes, and neither label is the subject of Khavinson’s 1990s papers. Animal-source capsules are inappropriate if the reader has a religious or allergy constraint on the source species. None of this replaces care for the actual organ disease. Pregnancy, unexplained bleeding, and hormone-sensitive cancers are specialist territory. A capsule is not estradiol.

Full 41-map: Khavinson bioregulators index · Bioregulator stacks

Research Use Cases

  • ✓Ovarian Cytomax identity (Ovagen is liver, not ovary)
  • ✓Not menopausal or fertility treatment

Dosing

PhaseDoseFrequencyNotes
Mini-Course / General Preventive (1 box)2 capsules (20 mg)Once daily for 10 days, 30 min before mealsStandard Khavinson mini-course (20 caps). Repeat every 6 months from age 35. Morning dosing preferred. Combine with Thyreogen (A-2) for thyroid-ovarian axis support.
Full Monthly Course (Perimenopause / Ovarian Support)2 capsules (20 mg)Twice daily for 30 days (120 caps = 2× 60-cap boxes)Bi-annual 30-day courses for perimenopausal adults, irregular cycles, low AMH/ovarian reserve, or menopausal symptom management. Core female hormonal stack: Zhenoluten (A-15) + Thyreogen (A-2) + Endoluten (A-8) for ovarian-thyroid-circadian HPO axis restoration.
Intensive / Female Hormonal Restoration Protocol2 capsules (20 mg)Twice daily, repeated monthlyFor perimenopause symptom management, premature ovarian insufficiency support, or fertility preparation protocol. Physician supervision required. Not a replacement for HRT. Max: 4 caps/day (40 mg).

Administration

Route / form
Oral capsules - swallowed with water. Cytomed Cytomaxes ship as capsules, not sublingual tablets and not lyophilized research vials.
Timing
Morning, with water, about 30 minutes before meals (empty stomach).
Empty stomach?
Yes - Empty stomach - about 30 minutes before meals. Cytomed boxes sometimes print “with food” because they are labeled as supplements; the manufacturer user-guide preference is before meals for absorption.

Zhenoluten: Not a research vial vs Oral capsule

Not a research vial
Bioavailability
Not applicable. This Cytomax SKU is not sold as a lyophilized research vial. There is no SubQ F% because Cytomed does not ship this complex as a cake.
Dose note
Do not reconstitute Zhenoluten. No BAC-water chart, no 5 mg vial math, no units-on-a-U-100 conversion. No dedicated cytogen on the 12-SKU NPCRIZ poster (none - Ovagen on NPCRIZ is the liver cytogen (EDL), not an ovary peptide). Do not invent one. There is no pharmaceutical-extract SKU that is this capsule in a syringe.
Advantages
  • No dedicated cytogen on the 12-SKU NPCRIZ poster (none - Ovagen on NPCRIZ is the liver cytogen (EDL), not an ovary peptide). Do not invent one.
  • There is no pharmaceutical-extract SKU that is this capsule in a syringe.
  • Do not pair a Zhenoluten capsule with an “Ovagen ovary vial.” Ovagen is liver cytogen. There is no ovary cytogen on the 12-SKU list. This is not HRT.
Considerations
  • Zhenoluten is an oral capsule complex. It is not a 5 mg lyophilized research vial.
  • Inventing recon math for a zero-mg Cytomax vial is how people inject the wrong product.
  • Not an official Cytomed sublingual tablet, IM ampoule, or eye drop either.
Oral capsule
Bioavailability
Not quantified in a Western PK study. Official Cytomed form is a swallowed capsule. PEPT1/LAT transport is class biology for short peptides, not an F% for this tissue mixture.
Dose note
Typical Cytomed labeling: 1–2 capsules daily in 10–30 day courses, swallowed with water about 30 minutes before meals (empty stomach). Manufacturer protocol, not an FDA label. Some boxes print “with food” because they are labeled as supplements; the timing copy we use is before meals.
Advantages
  • Official form for Zhenoluten: swallow the capsule with water. No reconstitution step and no 5 mg cake.
  • Female-reproductive Cytomax (Cytomed A-15). Ovagen is not a Cytomax and is not an ovary peptide on the official poster - it is liver.
  • Course-based (10–30 days, a few times a year in manufacturer folklore), not a daily forever drug.
Considerations
  • Ovary / female reproductive Cytomax is a peptide mixture / lot fingerprint, not a single CAS. English “V2” bottles are a later commercial layer, not a Khavinson RCT.
  • Russian school literature is not an FDA organ-disease label.
  • Third-party lingual SKUs exist in the wild. We do not claim sublingual as the official Cytomed Cytomax form.
Recommendation: Swallow Zhenoluten as oral capsules with water, about 30 minutes before meals. Ovary-focused Cytomax complex, not Ovagen, not estradiol, and not a reconstitution vial. Ovagen is liver. No ovary cytogen on the 12-SKU NPCRIZ poster. Pregnancy and hormone-sensitive cancers are specialist territory.

Timeline

Days 1 - 14
Granulosa and theca cell gene expression restoration initiated. Early regularization of cycle-related symptoms may begin.
Month 1–3
Improved hormonal rhythm consistency. Reduced hot flash frequency in perimenopausal users. Better sleep associated with improved estradiol baseline.
Month 3–6
Sustained ovarian steroidogenesis capacity support. Improved AMH trajectory in early-peri-menopausal women. Reduced FSH surge oscillation.

Who it is for

Perimenopause / Ovarian Aging (Ages 35+)

Low

Targets granulosa cell aromatase (CYP19A1) and theca cell StAR gene expression - restoring the ovary's own estradiol and progesterone synthesis capacity rather than providing exogenous hormones.

Female Fertility Preservation Protocol

Low

Used in fertility preparation protocols alongside Thyreogen (A-2) to optimize the thyroid-ovarian hormonal environment. Physician-supervised use in fertility medicine.

Safety & Considerations

Natural glandular extract (Cytomax) from bovine ovarian tissue, <10 kDa. Contains no estrogen, progesterone, or FSH/LH. Meets European/Russian veterinary standards. Physician oversight required for any known hormone-sensitive condition. Generally recognized as safe.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • Cytomax SKUs are oral capsules. Do not run SubQ reconstitution math on a zero-mg vial.
  • Lot-to-lot composition is a fingerprint, not one sequence.
  • This site will not treat the named organ disease from a peptide page.
  • English-language V2 / analog bottles are a later commercial layer, not a Khavinson RCT.

Verdict

Zhenoluten is a Cytomax capsule complex from Female reproductive system (ovary-focused Cytomax). It is not the paired cytogen, not a 5 mg research cake, and not a US supplement monograph. The organ story is in the dossier on this page.

Interactions & Contraindications

Hormone-sensitive conditions belong with a gynecologist, not a capsule page.

Frequently Asked Questions

Oral capsule or injection?▼
Zhenoluten is a Cytomax oral capsule: swallow with water, about 30 minutes before meals. It is not a 5 mg lyophilized research vial and not an official Cytomed sublingual tablet (third-party lingual SKUs exist in the wild). If you want a defined-sequence powder to reconstitute, that is the cytogen pair (none - Ovagen is liver cytogen, not an ovary peptide and not a Cytomax), not this complex. Do not run BAC math on a capsule SKU.
Is Ovagen the ovary peptide?▼
Not on the official NPCRIZ cytogen list. Ovagen is listed as liver. Zhenoluten is the female-reproductive Cytomax. Livagen is the other liver synthetic (KEDA).
Is this HRT?▼
No. Different modality, different evidence, different risks.
Pair peptide?▼
Do not pair Zhenoluten with Ovagen thinking you doubled the ovary bet. You doubled ovary-complex + liver-cytogen.
Capsules?▼
Yes. No vial math on the Cytomax SKU.
Is Zhenoluten hormonal?▼
No. Zhenoluten is filtered to <10 kDa and contains no estrogen, progesterone, or FSH. It delivers gene-regulatory signals to ovarian granulosa and theca cells to restore their own CYP19A1 (aromatase) and StAR-mediated steroidogenesis. It is not hormone replacement therapy.
What is the best stack for perimenopause?▼
Khavinson's female hormonal longevity triple stack: Zhenoluten (A-15, ovarian steroidogenesis) + Thyreogen (A-2, thyroid, since subclinical hypothyroidism worsens ovarian aging) + Endoluten (A-8, pineal/melatonin, since circadian disruption impairs GnRH pulsatility and HPO axis function). This addresses the ovarian, thyroid, and circadian triad of female hormonal aging.

References

  1. Khavinson VKh et al. “Tissue-specific effects of peptides.” Bulletin of Experimental Biology and Medicine (2001). PMID: 11713572
  2. Khavinson VKh, Lin’kova NS, Tarnovskaya SI “Short peptides regulate gene expression.” Bulletin of Experimental Biology and Medicine (2016). PMID: 27909961
  3. Khavinson VKh, Morozov VG “Peptides of pineal gland and thymus prolong human life.” Neuroendocrinology Letters (2003). PMID: 14523363

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Where to get itOral bioregulator

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Ovalis is Vita-Stream's US-made ovary bioregulator (Vita Peptides' own house line), a different product from Zhenoluten. No trial has tested it.

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Get Zhenoluten from Vita-Stream, which sells the GARMONIA Cytomax and Cytogen oral capsules. No reconstitution math on a capsule bottle.

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