Vitamin B6 (pyridoxine vs P5P) trials recruiting now
8 registrations that name vitamin B6 as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 8 registrations
Status
Phase
2US sites across 2 states
1
2 to 4
5 to 19
20 or more
All 8 registrations
RecruitingNCT06772220
Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease
No phase
Oregon Health and Science University
About 150 people
Started Mar 5, 2024
In plain words A study of vitamin B6 in people 40 to 90, run by Oregon Health and Science University. It plans to enroll about 150 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 40 to 90. Conditions: Parkinson&Amp;#39;s Disease.
Diagnosis of probable Parkinson's Disease according to Movement Disorders Society criteria.
Currently treated with levodopa at a minimum dose of 300 mg/day
Montreal Cognitive Assessment (MOCA) ≥15
Demonstrated capacity to provide informed consent.
4 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Folic Acid 1 MG; Vitamin B6 25 MG; Vitamin B12
Registered summary
This is a research study investigating elevated homocysteine in the blood of patients with Parkinson's disease who are currently receiving treatment with levodopa. We are evaluating if elevated homocysteine can be corrected using open label B vitamin therapy, as well as the impact of homocysteine levels on cognitive function.
Where, as registered
1 US site in 1 state.
RecruitingNCT07271966
B6 Administration for Levetiracetam-Associated Neurobehavioral Changes and Epilepsy
No phase
Duke University
About 50 people
Started May 29, 2026
In plain words A study of vitamin B6 in people 18 and older, run by Duke University. It plans to enroll about 50 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Brain Tumor Related Epilepsy (BTRE).
Age ≥ 18 years
Diagnosed with a primary brain tumor
Karnofsky Performance Status ≥ 70%
Have one or more documented seizures or transient events concerning for localization-related epilepsy requiring anti-seizure medication prophylaxis
10 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Vitamin B6 100 MG
Registered summary
This is a supportive care study to assess the effect of Vitamin B6 supplementation on mood-related side effects of levetiracetam in patients with brain tumors, who have already been prescribed levetiracetam for the prevention of seizures. This study will assess this effect from the perspective of both the patient and the patient's caregiver. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT06749756
Study on the Improvement of Microcirculation in Patients With Sepsis by Vitamin B6, Vitamin B12 and Vitamin C
No phase
Fan Zeng
About 296 people
Starts Feb 10, 2025 (estimated)
In plain words A study of vitamin B6 in people 18 to 85, run by Fan Zeng. It plans to enroll about 296 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 85. Conditions: Septic Shock.
Age ≥18 and < 85 years old
Admitted to ICU
Diagnosis of patients with SEPSIS 3.0 (diagnostic criteria) 4, SOFA score is 2-13 points
Sepsis is a kind of disease with high morbidity and mortality in ICU. At present, there is no specific treatment, and its pathogenesis is mainly excessive oxidative stress. Anti-inflammatory, antioxidant and immune-regulating drugs may produce better therapeutic effects, while vitamin B6, vitamin B12 and vitamin C have anti-inflammatory, antioxidant and immune-regulating effects. The full summary is on the listing.
Where, as registered
No US site; China (1).
RecruitingNCT06445933
Vitamin B6 and Depression in Pregnant and Peri-partum Women
No phase
National Taiwan University Hospital
About 150 people
Started Jul 5, 2024
In plain words A study of vitamin B6 in female participants 20 to 50, run by National Taiwan University Hospital. It plans to enroll about 150 people at 1 site, none in the US.
Without a personal history of depression, bipolar disorder, schizophrenia, or other mental health conditions.
The exclusion criteria are on the listing.
What it tests, as registered
Vitamin B6; Placebo
Registered summary
Perinatal depression is a highly prevalent and serious health issue during pregnancy. According to statistics, approximately one out of every ten postpartum women experiences this condition. Symptoms can manifest as mood fluctuations or emotional lows. Unfortunately, these symptoms are often overlooked by patients themselves or misinterpreted by others as normal adjustments to the new role of motherhood. Consequently, timely assistance and support are frequently lacking. The full summary is on the listing.
Where, as registered
No US site; Taiwan (1).
RecruitingNCT07877948
Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing
No phase
BREGO Life Sciences
About 100 people
Started Jul 22, 2025
In plain words A study of vitamin B6 in people 18 and older, run by BREGO Life Sciences. It plans to enroll about 100 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Diabetic Foot Ulcer (DFU); Diabetic Symmetrical Polyneuropathy.
Aged 18 years and above
Diagnosed with Type 2 Diabetes Mellitus
HbA1C of <8%
Symptoms of DSPN attributed by diabetes mellitus using Toronto Clinical Neuropathy Scoring (TCNS)
12 more inclusion criteria and the exclusion criteria are on the listing.
Diabetic symmetrical polyneuropathy (DSPN) is a common complication of diabetes that affects the nerves, especially in the legs and feet. It can cause pain, numbness, tingling, weakness, and loss of sensation. These problems can affect daily activities and quality of life. Loss of sensation can also increase the risk of foot wounds and problems with wound healing. This study is comparing two treatments in people with type 2 diabetes and DSPN. The full summary is on the listing.
Where, as registered
No US site; Malaysia (1).
RecruitingNCT05448365
Vitamin D, Epigallocatechin Gallate, D-chiro-inositol and Vitamin B6 in Uterine Fibroid
No phase
Lo.Li.Pharma s.r.l
About 60 people
Started Jul 1, 2022
In plain words A study of vitamin B6 in female participants 30 to 40, run by Lo.Li.Pharma s.r.l. It plans to enroll about 60 people at 2 sites, none in the US.
The study will evaluate the impact on uterine fibroids' volume of a combination of natural molecules including Epigallocatechin gallate, Vitamin D, D-chiro-inositol and Vitamin B6. The patients will be evaluated at baseline and after three months of treatment with placebo or product.
Where, as registered
No US site; Italy (2).
Not yet recruitingNCT06625632
Effect of Kinesiotape on Emesis in Pregnant Women
No phase
Cairo University
About 50 people
Starts Oct 7, 2024 (estimated)
In plain words A study of vitamin B6 in female participants 20 to 35, run by Cairo University. It plans to enroll about 50 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 20 to 35. Conditions: Emesis Pregnancy.
Fifty pregnant women at 6th to 12th weeks of gestation diagnosed with mild to moderate nausea and vomiting.
The diagnosis of EG is confirmed by Rhodes index.
Their ages will be ranged from 20 to 35years old.
Their body mass index will be less than 30 kg/m2.
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Antiemetic Drug; Vitamin B6; Home care advice; Kinesiotaping
Registered summary
This study will be conducted to investigate the effect of kinesiotaping on emesis in pregnant women.
Where, as registered
No US site; Egypt (1).
Not yet recruitingNCT06369350
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
Early phase 1
Milton S. Hershey Medical Center
About 30 people
Starts Dec 2027 (estimated)
In plain words An early phase 1 study of vitamin B6 in people 21 to 70, run by Milton S. Hershey Medical Center. It plans to enroll about 30 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 21 to 70; healthy volunteers accepted. Conditions: Ischemia Reperfusion Injury; Peripheral Artery Disease.
Are males and females at least 21- 70 years of age (inclusive)
Capable of giving informed consent
Are of any race or ethnicity
Can communicate in English
5 more inclusion criteria and the exclusion criteria are on the listing.
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury. We are interested in a protein called P2X3, of which function can be blocked by vitamin B6, in the neurons of our nervous system. It is very important for blood pressure regulation. We would like to see if the P2X3 plays a role in patients' rising blood pressure during exercise. The full summary is on the listing.