Vitamin B12 (methylcobalamin vs cyanocobalamin) trials recruiting now
9 registrations that name vitamin B12 as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 9 registrations
Status
Phase
1US sites across 1 state
1
2 to 4
5 to 19
20 or more
All 9 registrations
RecruitingNCT06772220
Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease
No phase
Oregon Health and Science University
About 150 people
Started Mar 5, 2024
In plain words A study of vitamin B12 in people 40 to 90, run by Oregon Health and Science University. It plans to enroll about 150 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 40 to 90. Conditions: Parkinson&Amp;#39;s Disease.
Diagnosis of probable Parkinson's Disease according to Movement Disorders Society criteria.
Currently treated with levodopa at a minimum dose of 300 mg/day
Montreal Cognitive Assessment (MOCA) ≥15
Demonstrated capacity to provide informed consent.
4 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Folic Acid 1 MG; Vitamin B6 25 MG; Vitamin B12
Registered summary
This is a research study investigating elevated homocysteine in the blood of patients with Parkinson's disease who are currently receiving treatment with levodopa. We are evaluating if elevated homocysteine can be corrected using open label B vitamin therapy, as well as the impact of homocysteine levels on cognitive function.
Where, as registered
1 US site in 1 state.
RecruitingNCT07877948
Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing
No phase
BREGO Life Sciences
About 100 people
Started Jul 22, 2025
In plain words A study of vitamin B12 in people 18 and older, run by BREGO Life Sciences. It plans to enroll about 100 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Diabetic Foot Ulcer (DFU); Diabetic Symmetrical Polyneuropathy.
Aged 18 years and above
Diagnosed with Type 2 Diabetes Mellitus
HbA1C of <8%
Symptoms of DSPN attributed by diabetes mellitus using Toronto Clinical Neuropathy Scoring (TCNS)
12 more inclusion criteria and the exclusion criteria are on the listing.
Diabetic symmetrical polyneuropathy (DSPN) is a common complication of diabetes that affects the nerves, especially in the legs and feet. It can cause pain, numbness, tingling, weakness, and loss of sensation. These problems can affect daily activities and quality of life. Loss of sensation can also increase the risk of foot wounds and problems with wound healing. This study is comparing two treatments in people with type 2 diabetes and DSPN. The full summary is on the listing.
Where, as registered
No US site; Malaysia (1).
RecruitingNCT07443410
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
No phase
University Hospital Heidelberg
About 60 people
Started Oct 25, 2024
In plain words A study of vitamin B12 in people 18 and older, run by University Hospital Heidelberg. It plans to enroll about 60 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older; healthy volunteers accepted. Conditions: Periodontitis, Adult; Periodontitis (Stage 3); Periodontitis Stage IV.
Age ≥ 18 years
Stage III or IV periodontitis (localized or generalized)
Ability to provide informed consent
Written informed consent including data protection consent
Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response. Standard non-surgical periodontal therapy (NSPT) is primarily mechanical and, in selected cases, may be accompanied by antiseptics or systemic antibiotics. Targeted modulation of the oral microbiome ("microbiome engineering") is currently not part of routine periodontal care due to limited high-quality evidence. The full summary is on the listing.
Where, as registered
No US site; Germany (1).
RecruitingNCT05785585
Effect of Methylcobalamin and Cyanocobalamin Consumption on Vitamin B12 Nutritional Status
No phase
Fundació Eurecat
About 54 people
Started Sep 9, 2023
In plain words A study of vitamin B12 in people 18 and older, run by Fundació Eurecat. It plans to enroll about 54 people at 2 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older; healthy volunteers accepted. Conditions: Vitamin B12 Nutritional Deficiency.
Men and women aged 18 years or older who follow a vegetarian diet.
Present serum vitamin B12 levels of 148-221 pmol/L and absence of symptoms associated with vitamin B12 deficiency.
Sign the informed consent.
Read, write and speak Catalan or Spanish.
The exclusion criteria are on the listing.
What it tests, as registered
Methylcobalamin; Cyanocobalamin group; Control group
Registered summary
Vitamin B12 (B12, Cobalamin) is an essential micronutrient that humans are not capable of synthesizing and therefore must be ingested through food. In nature, B12 is basically only present in foods of animal origin. B12 deficiency is a clinically important condition that is associated with several metabolic disorders such as megaloblastic anemia, hyperhomocysteinemia, and cardiovascular, cerebrovascular, and neurological disorders. Therefore an optimal intake of B12 is important. B12 deficiency occurs when B12 stores are depleted due to inadequate dietary intake or impaired absorption of B12. The full summary is on the listing.
Where, as registered
No US site; Spain (2).
RecruitingNCT07048860
ICOPE INTENSE-K Pilot Study
No phase
University Hospital, Toulouse
About 40 people
Started Jul 9, 2025
In plain words A study of vitamin B12 in people 65 to 85, run by University Hospital, Toulouse. It plans to enroll about 40 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 65 to 85; healthy volunteers accepted. Conditions: Ageing.
Independent-living (ADL ≥5/6)
Men and women
Mobility impairment (5 Chair-rise test >12 seconds)
Sedentarism (spend six or more hours per day sitting or lying down)
2 more inclusion criteria and the exclusion criteria are on the listing.
ICOPE could constitute the reference model of care for healthy aging. More specifically, our hypothesis is that the intervention implemented in ICOPE may directly or indirectly prevent immuno-senescence, the loss of mobility and the cognitive decline. In future Geroscience clinical trials, ICOPE-Intense could become a benchmark to reduce the rate of aging with a strong non-pharmacological intervention and state a reference intervention to compare with new gerotherapeutic drugs.
Where, as registered
No US site; France (1).
RecruitingNCT06581900
Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPA
Observational
CHU de Reims
About 29 people
Started Nov 27, 2024
In plain words An observational study of vitamin B12 in people 2 to 18, run by CHU de Reims. It plans to enroll about 29 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 2 to 18. Conditions: Sickle Cells Patients.
Sickle cells patient
Age between 2 and 18 years old
Being affiliated with social security
The exclusion criteria are on the listing.
What it tests, as registered
Vitamin B12
Registered summary
Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis (Limit : 5000 characters) The sickle cells anemia is a monogenic disease linked to the presence of Hemoglobin S due to a mutation in the Hemoglobin Beta chain. The lack of circulating oxygen induces a polymerization of the Hemoglobin S which change the red cell conformation into sickle. Those cells interact and causes vaso-occlusive crisis (CVO). The MEOPA is a medical gas used as an antalgic and a sedative especially in sickle cells disease patients. The full summary is on the listing.
Where, as registered
No US site; France (1).
RecruitingNCT06639789
Effect of a New Formulation of Vitamin B12 on Physical and Mental
No phase
Francisco Javier Martínez Noguera
About 18 people
Started Jul 1, 2024
In plain words A study of vitamin B12 in male participants 18 to 45, run by Francisco Javier Martínez Noguera. It plans to enroll about 18 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 to 45; healthy volunteers accepted. Conditions: Performance Enhancing Product Use.
Male cyclists who have competed in both junior and amateur categories.
Cycling between 6-15 hours of training per week.
BMI between 18-25 kg/m2.
The exclusion criteria are on the listing.
What it tests, as registered
Vitamin B12 (B12); PLACEBO (PLA)
Registered summary
This clinical study evaluates the effect of acute intake of a new vitamin B12 formulation on anaerobic and cognitive performance variables. One of the limiting factors for the potential beneficial effects of vitamin B12 is its bioavailability. This new formula improves this aspect, so that by improving plasma levels of B12 we will be able to relate whether this situation may be related to improved performance or cognitive tasks.
Where, as registered
No US site; Spain (1).
Not yet recruitingNCT07344974
Hand and Foot Bath for Taxane-Induced Peripheral Neurotoxicity
Phase 4
Peking University Cancer Hospital & Institute
About 78 people
Starts Feb 1, 2026 (estimated)
In plain words A Phase 4 study of vitamin B12 in people 18 and older, run by Peking University Cancer Hospital & Institute. It plans to enroll about 78 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Breast Cancer.
Pathologically confirmed breast cancer;
Development of grade ≥1 peripheral neurotoxicity after receiving a taxane-containing regimen, with continuation of this regimen for at least two additional cycles;
Age ≥18 years, male or female;
ECOG performance status score 0-1;
11 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Traditional Chinese medicine (TCM) hand and foot baths; Methylcobalamin (methylB12)
Registered summary
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity of taxane-based agents, with an incidence of 57%-83%. Patients frequently develop fingertip numbness, reduced tactile sensation, and other neuropathic symptoms, which significantly impair quality of life. The severity of CIPN is strongly associated with cumulative drug dosage. Current management strategies remain inadequate, and no high-level clinical recommendations are available. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07697196
Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration
No phase
IRCCS San Raffaele
About 42 people
Starts Jul 2026 (estimated)
In plain words A study of vitamin B12 in female participants 25 and older, run by IRCCS San Raffaele. It plans to enroll about 42 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 25 and older. Conditions: HPV Infection; HPV Integration; HPV Disease; HPV Genital Infection; HPV Persistence; Low Grade Squamous Intraepithelial Lesions of the Cervix.
Age ≥ 25 years old
Positive HPV DNA test with genotyping 9-24 months prior to Day 0
Positive HPV DNA test with genotyping at Day 0
Presence of an HPV-related cervical lesion within 5-24 months prior to Day 0. This lesion will be defined alternatively as:
6 more inclusion criteria and the exclusion criteria are on the listing.
This interventional, single-center, open-label randomized clinical study evaluates the efficacy of an oral dietary supplement (Pervistop®) in women with persistent Human Papillomavirus (HPV) infection. The supplement is a combination of four natural molecules: Epigallocatechin gallate (EGCG), folic acid (FA), vitamin B12 (B12), and hyaluronic acid (HA).The primary objective is to describe the effect of this association on HPV DNA integration into the host genome by measuring the clearance rate of viral oncoproteins E6 and E7. The full summary is on the listing.